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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic diversity in Ebola virus: Phylogenetic and in silico structural studies of Ebola viral proteins
Asian Pacific Journal of Tropical Medicine, Volume 9, No. 4, Year 2016
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Description
Objective: To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola Virus. Methods: Sequences retrieved from public databases, the selective pressure analysis and the homology modeling based on the all protein (nucleoprotein, VP35, VP40, soluble glycoprotein, small soluble glycoprotein, VP30, VP24 and polymerase) were used. Results: Structural proteins VP24, VP30, VP35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral treatment. On the contrary, nucleoprotein, polymerase and soluble glycoprotein have high mutation frequency. Conclusions: Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions. © 2016 Hainan Medical College.
Authors & Co-Authors
Grifoni, Alba
Bulgaria, Sofia
Proxagen Ltd.
Lo Presti, Alessandra
Italy, Rome
Istituto Superiore Di Sanita
Giovanetti, Marta
Italy, Rome
Istituto Superiore Di Sanita
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Montesano, C.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Amicosante, Massimo
Bulgaria, Sofia
Proxagen Ltd.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Colizzi, Vittorio C.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Lai, Alessia
Italy, Milan
Università Degli Studi Di Milano
Zehender, Gianguglielmo
Italy, Milan
Università Degli Studi Di Milano
Cella, Eleonora
Italy, Rome
Istituto Superiore Di Sanita
Italy, Rome
Sapienza Università Di Roma
Angeletti, Silvia
Italy, Rome
University Hospital Campus Bio-medico
Ciccozzi, M.
Italy, Rome
Istituto Superiore Di Sanita
Italy, Rome
Università Campus Bio-medico Di Roma
Statistics
Citations: 11
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.apjtm.2016.03.016
ISSN:
19957645
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases