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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
EPA and DHA as markers of nutraceutical treatment response in major depressive disorder
European Journal of Nutrition, Volume 59, No. 6, Year 2020
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Description
Purpose: Depression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment of biomarkers may reveal subsets of patients who are responsive to nutraceutical treatment, which may facilitate a personalized approach to treating depression. Methods: This is a post hoc analysis of an 8-week, double-blind, randomized, controlled trial (n = 158) investigating a combination nutraceutical comprising Omega-3 (EPA 1 g/DHA 656 mg), SAMe, zinc, 5-HTP, folinic acid, and co-factors versus placebo for the treatment of Major Depressive Disorder. The study explored levels of polyunsaturated fatty acids, folate, vitamin B12, zinc, homocysteine, and BDNF as possible predictors and correlates of response to nutraceutical supplementation. Results: Concentrations of EPA and DHA in red cell membranes increased in response to treatment and were significantly correlated with a decrease in depressive symptoms during active treatment (p = 0.003 and p = 0.029; respectively). Higher baseline levels of omega-6 fatty acid also correlated with depression reduction in the active treatment group (p = 0.011). No other biomarkers were associated with a lessening of depressive symptoms. Conclusion: Changes in fatty acid levels resulting from a nutraceutical combination containing EPA and DHA provide a response biomarker in treating depression. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Authors & Co-Authors
Cribb, Lachlan
Australia, Melbourne
University of Melbourne
Firth, Joseph
Australia, Penrith
Western Sydney University
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
Mischoulon, David
United States, Boston
Massachusetts General Hospital
Bousman, Chad A.
Canada, Calgary
University of Calgary
Australia, Melbourne
University of Melbourne
Stough, Con K.K.
Australia, Hawthorn
Swinburne University of Technology
Berk, Michael
Australia, Melbourne
University of Melbourne
Australia, Geelong
Barwon Health
Australia, Melbourne
The Florey
Australia, Melbourne
Orygen Youth Health
Ng, Chee H.
Australia, Melbourne
University of Melbourne
Sarris, Jerome
Australia, Melbourne
University of Melbourne
Australia, Penrith
Western Sydney University
Statistics
Citations: 18
Authors: 8
Affiliations: 11
Identifiers
Doi:
10.1007/s00394-019-02090-6
ISSN:
14366207
Research Areas
Disability
Mental Health