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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
All-cause mortality in treated HIV-infected adults with CD4 ≥500/mm3 compared with the general population: Evidence from a large European observational cohort collaboration
International Journal of Epidemiology, Volume 41, No. 2, Year 2012
Notification
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Description
Background: Using data from a large European collaborative study, we aimed to identify the circumstances in which treated HIV-infected individuals will experience similar mortality rates to those of the general population. Methods Adults were eligible if they initiated combination anti-retroviral treatment (cART) between 1998 and 2008 and had one prior CD4 measurement within 6 months. Standardized mortality ratios (SMRs) and excess mortality rates compared with the general population were estimated using Poisson regression. Periods of follow-up were classified according to the current CD4 count. Results: Of the 80 642 individuals, 70% were men, 16% were injecting drug users (IDUs), the median age was 37 years, median CD4 count 225/mm3 at cART initiation and median follow-up was 3.5 years. The overall mortality rate was 1.2/100 person-years (PY) (men: 1.3, women: 0.9), 4.2 times as high as that in the general population (SMR for men: 3.8, for women: 7.4). Among 35 316 individuals with a CD4 count ≥500/mm3, the mortality rate was 0.37/100 PY (SMR 1.5); mortality rates were similar to those of the general population in non-IDU men [SMR 0.9, 95% confidence interval (95% CI) 0.7-1.3] and, after 3 years, in women (SMR 1.1, 95% CI 0.7-1.7). Mortality rates in IDUs remained elevated, though a trend to decrease with longer durations with high CD4 count was seen. A prior AIDS diagnosis was associated with higher mortality. Conclusions: Mortality patterns in most non-IDU HIV-infected individuals with high CD4 counts on cART are similar to those in the general population. The persistent role of a prior AIDS diagnosis underlines the importance of early diagnosis of HIV infection. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2011; all rights reserved.
Authors & Co-Authors
Lewden, Charlotte
France, Bordeaux
Université de Bordeaux
Bouteloup, Vincent
France, Bordeaux
Université de Bordeaux
de Wit, Stéphane A.
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Belgium
St Pierre Cohort
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Mocroft, Amanda A.
United Kingdom, London
Ucl Medical School
United Kingdom
Eurosida
Wasmuth, Jan Christian
Germany, Bonn
Universität Bonn
van Sighem, Ard I.
Netherlands, Amsterdam
Stichting Hiv Monitoring
Kirk, Ole
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
United Kingdom
Eurosida
Obel, Niels
Denmark, Copenhagen
Rigshospitalet
Denmark
Danish Hiv Cohort
Ghosn, Jade
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France
Anrs Co6 Primo
Dabis, Franćois Ç.Ois
France, Bordeaux
Université de Bordeaux
France
Anrs Co3 Aquitaine
Mary-Krause, Murielle
France, Paris
Inserm
France
Anrs Co4 Fhdh
France, Paris
Sorbonne Université
Leport, Catherine
France, Paris
Université Paris Cité
France
Anrs Co8 Copilote
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Pérez-Hoyos, Santiago
Spain, Barcelona
Vall D'hebron Institut de Recerca
Stephan, Christoph J.
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Castagna, Antonella
Italy, Milan
Irccs Ospedale San Raffaele
Antinori, Andrea
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
D'Arminio Monforte, Antonella D.
Italy, Milan
Ospedale Fatebenefratelli e Oftalmico
Torti, Carlo
Italy, Brescia
Spedali Civili Di Brescia
Italy
Italian Master Cohort
Mussini, Cristina
Italy, Modena
Azienda Ospedaliero - Universitaria Di Modena
Italy, Modena
Modena Cohort
Calmy, Alexandra L.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Teira, Ramón M.
Unknown Affiliation
Egger, Matthias
Switzerland, Bern
University of Bern
Grarup, Jesper
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen Regional Coordinating Centre
Zangerle, Robert
Austria
Ahivcos
Touloumi, Giota
Greece, Athens
Amacs
Warszawski, Josiane
France
Anrs Co1 Epf/anrs Co11 Observatoire Epf
Meyer, Laurence J.
France
Anrs Co2 Seroco
Reiss, Peter
Netherlands
Athena
De Wolf, Frank
Netherlands
Athena
Bucher, Heiner C.
United Kingdom, Hull
Cascade
Prins, Maria
United Kingdom, Hull
Cascade
Gibb, Diana M.
Unknown Affiliation
Fätkenheuer, Gerd
Unknown Affiliation
del Amo, Julia
Unknown Affiliation
Thorne, Claire N.
Unknown Affiliation
Noguera-Julián, Antoni Diez
Unknown Affiliation
Brockmeyer, Norbert Hermann
Unknown Affiliation
Ramos-Rincón, José Manuel
Spain, Madrid
Madrid Pmtct Cohort
Battegay, Manuel
Unknown Affiliation
Rauch, Andri
Switzerland
Shcs
Tookey, Pat A.
United Kingdom
Nshpc
Miró, José María
Spain
Piscis
Goetghebuer, Tessa
Belgium
St Pierre Paediatric Cohort
Garrido, Myriam
Unknown Affiliation
Haerry, David Hans Ulrich
Unknown Affiliation
Weller, Ian V.D.
United Kingdom, London
University College London
Costagliola, Dominique G.
France
Fhdh
Chêne, Geneviève
Unknown Affiliation
Raffi, François
Unknown Affiliation
Staszewski, Schlomo
Unknown Affiliation
Ridolfo, Anna Lisa
Unknown Affiliation
Colin, Céline
Unknown Affiliation
Schwimmer, Christine
Unknown Affiliation
Kjaer, Jesper
Unknown Affiliation
Bohlius, Julia
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Dorrucci, Maria
Unknown Affiliation
Furrer, Hansjakob
Unknown Affiliation
Lambotte, Olivier
Unknown Affiliation
Matheron, Sophie
Unknown Affiliation
Miró, José Mª
Unknown Affiliation
Paredes, Roger
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Scherrer, Alexandra U.
Unknown Affiliation
Smit, Colette
Unknown Affiliation
Sterne, Jonathan A.C.
Unknown Affiliation
Thíébaut, Rodolphe
Unknown Affiliation
von Wyl, Viktor
Unknown Affiliation
Wittkop, Linda
Unknown Affiliation
Statistics
Citations: 250
Authors: 71
Affiliations: 45
Identifiers
Doi:
10.1093/ije/dyr164
ISSN:
03005771
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female