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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Fluconazole mucoadhesive buccal films: In vitro/in vivo performance
Current Drug Delivery, Volume 6, No. 1, Year 2009
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Description
Fluconazole mucoadhesive buccal films were prepared using film forming polymers namely; hydroxypropyl methyl cellulose (HPMC), hydroxyethyl cellulose (HEC), chitosan, Eudragit and sodium alginate (SALG) either alone or in combination with bioadhesive polymers. The bioadhesive polymers studied were sodium carboxymethyl cellulose (SCMC), Carbopol 974P, and polycarbophil (AA-A). The prepared films were characterized by means of film thickness, surface pH, swelling capacity, in vitro adhesion, in vivo residence time, in vitro drug release and in vivo drug release to determine the amount of drug release from selected film formulae using microbiological assay and HPLC. Optimum release behavior, convenient bioadhesion, acceptable elasticity were exhibited by film containing 2% HPMC and 1% SCMC (fresh or stored for 6 months). Determination of the amount of drug released in saliva after application of the selected fluconazole films confirmed the ability of the film to deliver the drug over a period of approximately 300 minutes and to reduce side effects and possibility of drug interaction encountered during systemic therapy of fluconazole, which would be beneficial in the case of oral candidiasis. © 2009 Bentham Science Publishers Ltd.
Authors & Co-Authors
Yehia, Soad Ali
Egypt, Cairo
Faculty of Pharmacy
El Gazayerly, Omaima N.
Egypt, Cairo
Faculty of Pharmacy
Basalious, Emad B.
Egypt, Cairo
Faculty of Pharmacy
Statistics
Citations: 110
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.2174/156720109787048195
ISSN:
15672018
Research Areas
Health System And Policy