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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel strategies implemented to ensure high participant retention rates in a community based HIV prevention effectiveness trial in South Africa and Zimbabwe
Contemporary Clinical Trials, Volume 30, No. 5, Year 2009
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Description
Background: The identification of new HIV prevention methods that women can initiate themselves are urgently needed, particularly in high prevalence settings. HIV prevention trials must be designed with large sample sizes and/or substantial follow-up periods to ensure enough statistical power to measure product effectiveness. This paper describes the attendance rates of the Methods for Improving Reproductive Health in Africa (MIRA) trial, reasons for missed visits, and strategies used to retain participants; and examines demographic and behavioural predictors of retaining women. Methods: HIV negative, sexually active females were enrolled into the MIRA trial in Zimbabwe and South Africa. Once enrolled, women were expected to visit the clinic at 2 weeks and quarterly thereafter for 12 to 24 months. Tabulations of visit-specific retention rates are presented, along with a descriptive summary of retention strategies established prior to and in response to challenges incurred during implementation. Both univariate and multivariate logistic regression models were created in STATA to examine predictors of being retained vs. lost-to-follow-up. Results: At the three sites, the final retention rates were 94%, 93% and 89% for Zimbabwe, Durban and Johannesburg, respectively. This was achievable through intensive outreach efforts toward the latter part of the trial and a commitment from all staff. Each site implemented several retention strategies. Conclusion: The high retention rates were achievable in this trial through added staff efforts and resources. Community involvement was also crucial to achieve these rates. Retention of trial participants should be considered during trial design and implemented from the onset. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Gappoo, Sharika
South Africa, Tygerberg
South African Medical Research Council
Montgomery, Elizabeth T.
United States, Research Triangle Park
Rti International
Gerdts, Caitlin Elisabeth
United States, Research Triangle Park
Rti International
Naidoo, Sarita
South Africa, Tygerberg
South African Medical Research Council
Chidanyika, Agnes
Zimbabwe, Harare
Uz-ucsf Collaborative Program in Women's Health
Nkala, B.
Unknown Affiliation
Ramjee, Gita A.
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 29
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.cct.2009.05.002
ISSN:
15517144
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
South Africa
Zimbabwe
Participants Gender
Female