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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients
American Journal of Hematology, Volume 42, No. 3, Year 1993
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Description
Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age‐ and sex‐matched Nigerian and U.S. steady‐state SS patients were compared. Splenomegaly was found in 22.3% of Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean ± SE of IgG‐specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 ± 2,036; 9,334 ± 2,980 in those with spleens between 1 and 5 cm, 16,201 ± 4,502 in those with spleens between 6 and 10 cm, and 22,445 ± 8,456 in those with spleens above 10 cm. Coexistent α‐thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Adekile, Adekunle D.
United States, Augusta
Medical College of Georgia
Nigeria, Ife
Obafemi Awolowo University
McKie, Kathleen M.
United States, Augusta
Medical College of Georgia
Adeodu, Oluwagbemiga Oyewole
Nigeria, Ife
Obafemi Awolowo University
Sulzer, Alexander J.
United States, Atlanta
Centers for Disease Control and Prevention
Liu, J. ‐S
United States, Augusta
Medical College of Georgia
McKie, Virgil C.
United States, Augusta
Medical College of Georgia
Kutlar, Ferdane
United States, Augusta
Medical College of Georgia
Ramachandran, M.
United States, Augusta
Medical College of Georgia
Kaine, Winifred N.
Nigeria, Naukka
University of Nigeria
Akenzua, Gregory I.
Nigeria, Benin
University of Benin
Okolo, Angela Anene
Nigeria, Benin
University of Benin
Asindi, Asindi Andrew
Nigeria, Calabar
University of Calabar
Obinyan, E. A.
Nigeria, Zaria
Ahmadu Bello University
Ogala, Williams Nuhu
Nigeria, Zaria
Ahmadu Bello University
Ibrahim, Mu'utassim
Nigeria, Sokoto
Usmanu Danfodiyo University
Huisman, Titus Hendrik Jan
United States, Augusta
Medical College of Georgia
Statistics
Citations: 36
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1002/ajh.2830420313
ISSN:
03618609
e-ISSN:
10968652
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study