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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Paclitaxel Encapsulated in Halloysite Clay Nanotubes for Intestinal and Intracellular Delivery
Journal of Pharmaceutical Sciences, Volume 106, No. 10, Year 2017
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Description
Naturally formed halloysite tubules have a length of 1 μm and lumens with a diameter of 12-15 nm which can be loaded with drugs. Halloysite's biocompatibility allows for its safe delivering to cells at a concentration of up to 0.5 mg/mL. We encapsulated the anticancer drug paclitaxel in halloysite and evaluated the drug release kinetics in simulated gastric and intestinal conditions. To facilitate maximum drug release in intestinal tract, halloysite tubes were coated with the pH-responsive polymer poly(methacrylic acid-co-methyl methacrylate). Release kinetics indicated a triggered drug release pattern at higher pH, corresponding to digestive tract environment. Tablets containing halloysite, loaded with paclitaxel, as a compression excipient were formulated with drug release occurring at a sustained rate. In vitro anticancer effects of paclitaxel-loaded halloysite nanotubes were evaluated on human cancer cells. In all the treated cell samples, polyploid nuclei of different sizes and fragmented chromatin were observed, indicating a high therapeutic effect of halloysite formulated paclitaxel. © 2017 American Pharmacists Association®
Authors & Co-Authors
Lvov, Y.
United States, Ruston
Louisiana Tech University
Russian Federation, Moscow
National University of Oil and Gas «gubkin University»
de Villiers, Melgardt M.
United States, Madison
University of Wisconsin-madison
Vinokurov, Vladimir A.
Russian Federation, Moscow
National University of Oil and Gas «gubkin University»
Statistics
Citations: 99
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1016/j.xphs.2017.05.034
ISSN:
00223549
Research Areas
Cancer