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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps Volunteers in Morocco
Gastroenterology, Volume 76, No. 6, Year 1979
Notification
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Description
A second randomized double-blind study to determine the efficacy of doxycycline, 100 mg daily, for the prevention of travelers' diarrhea was carried out among 50 Peace Corps Volunteers during their first 10 wk in Morocco. The volunteers took either doxycycline or placebo for 3 wk, and were observed for an additional 7 wk. Eleven of 24 taking the placebo and 2 of 26 taking doxycycline had travelers' diarrhea during the treatment period (P < 0.01). One week after cessation of the doxycycline, however, persons in that group developed an increase in frequency of travelers' diarrhea (P < 0.05) so that by 3 wk after the drug was stopped, there were no differences between the groups. Enterotoxigenic E. coli, most of which were sensitive to doxycycline, were the most frequently isolated pathogens during the entire study. This study corroborates the effectiveness of doxycycline prophylaxis for travelers' diarrhea. © 1979.
Authors & Co-Authors
Sack, Richard Bradley
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Froehlich, Jean L.
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Zulich, Alan W.
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Hidi, Dolores Sidi
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Kapikian, Albert Z.
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Ørskov, Frits
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Orskóv, Ida
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Greenberg, Harry B.
United States, Baltimore
Johns Hopkins School of Medicine
Morocco, Rabat
United States Peace Corps
United States, Bethesda
National Institutes of Health Nih
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 58
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/0016-5085(79)90403-7
ISSN:
00165085
Research Areas
Disability
Study Design
Cohort Study
Study Locations
Morocco