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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A microsatellite-based index map of human chromosome 11
Human Molecular Genetics, Volume 2, No. 7, Year 1993
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Description
We have constructed a continuous Index map of 25 micosatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygositles of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 105: 1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the Index map with the cytogenetic map. The map will facilltate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11. © 1993 Oxford University Press.
Authors & Co-Authors
Litt, M.
Unknown Affiliation
Kramer, P. L.
Unknown Affiliation
Hauge, X. Y.
Unknown Affiliation
Weber, James L.
Unknown Affiliation
Wang, Z.
Unknown Affiliation
Wilkle, P. J.
Unknown Affiliation
Holt, M. S.
Unknown Affiliation
Mishra, Santosh K.
Unknown Affiliation
Donis-Keller, Helen
Unknown Affiliation
Warnich, Louise
Unknown Affiliation
Retief, Andries E.
Unknown Affiliation
Jones, C.
Unknown Affiliation
Welssenbach, Jean
Unknown Affiliation
Statistics
Citations: 40
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1093/hmg/2.7.909
ISSN:
09646906
Research Areas
Genetics And Genomics
Participants Gender
Male
Female