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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prospective progression from high-prevalence disorders to bipolar disorder: Exploring characteristics of pre-illness stages
Journal of Affective Disorders, Volume 183, Article 7402, Year 2015
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Description
Abstract Background Identification of risk factors within precursor syndromes, such as depression, anxiety or substance use disorders (SUD), might help to pinpoint high-risk stages where preventive interventions for Bipolar Disorder (BD) could be evaluated. Methods We examined baseline demographic, clinical, quality of life, and temperament measures along with risk clusters among 52 young people seeking help for depression, anxiety or SUDs without psychosis or BD. The risk clusters included Bipolar At-Risk (BAR) and the Bipolarity Index as measures of bipolarity and the Ultra-High Risk assessment for psychosis. The participants were followed up for 12 months to identify conversion to BD. Those who converted and did not convert to BD were compared using Chi-Square and Mann Whitney U tests. Results The sample was predominantly female (85%) and a majority had prior treatment (64%). Four participants converted to BD over the 1-year follow up period. Having an alcohol use disorder at baseline (75% vs 8%, χ2=14.1, p<0.001) or a family history of SUD (67% vs 12.5%, χ2=6.0, p=0.01) were associated with development of BD. The sub-threshold mania subgroup of BAR criteria was also associated with 12-month BD outcomes. The severity of depressive symptoms and cannabis use had high effects sizes of association with BD outcomes, without statistical significance. Conclusions and limitations The small number of conversions limited the power of the study to identify associations with risk factors that have previously been reported to predict BD. However, subthreshold affective symptoms and SUDs might predict the onset of BD among help-seeking young people with high-prevalence disorders. © 2015 Elsevier B.V.
Authors & Co-Authors
Cotton, Sue M.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Nelson, Barnaby
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Davey, Christopher G.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
McGorry, Patrick D.
Australia, Melbourne
Orygen Youth Health
Australia, Melbourne
University of Melbourne
Berk, Michael
Australia, Melbourne
Orygen Youth Health
Australia, Geelong
Deakin University
Australia, Melbourne
The Florey
Bechdolf, Andreas
Australia, Melbourne
University of Melbourne
Germany, Berlin
Vivantes Klinikum am Urban
Germany, Koln
Universität zu Köln
Statistics
Citations: 32
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/j.jad.2015.04.025
ISSN:
01650327
Research Areas
Disability
Mental Health
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female