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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Termination of second trimester pregnancy by intramuscular injection of 16-phenoxy-ω-17,18,19,20-tetranor-PGE
2
methyl sulphonylamide
International Journal of Gynecology and Obstetrics, Volume 20, No. 5, Year 1982
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Description
Two doses of the prostaglandin analogue 16-phenoxy-ω-17,18,19,20-tetranor-PGE2 methyl sulphonylamide were compared in a randomized multicentre trial in 6 centres for the termination of second trimester pregnancy. A total of 295 patients were treated with either 0.5 mg or 1.0 mg given by intramuscular injection every 4 h or 8 h, respectively. The 1-mg dose was more effective in inducing an abortion than the lower dose but the difference was not statistically significant. Eighty-four per cent of the patients aborted within 30 h from the onset of treatment. The induction-abortion interval was approximately 15 h in both groups. The incidence of incomplete abortion, heavy blood loss and blood transfusion was similar for both treatments. Cervical lacerations occurred in 1.3% of patients given the smaller dose and 2.1% of the larger dose. In one patient belonging to the latter group an anterior rupture of the lower uterine segment was diagnosed necessitating hysterectomy. Fifty per cent of the patients had no vomiting and 90% no diarrhea. The frequency of gastrointestinal side effects was slightly higher with the 1-mg dose. The major advantages of this treatment are the simplicity of administration and the low frequency of gastrointestinal side effects in comparison with prostaglandin F analogues. © 1982.
Authors & Co-Authors
Krishna, U.
India, Mumbai
Seth gs Medical College and Kem Hospital
Narone, J. N.
Zambia, Lusaka
University of Zambia
Hingorani, V.
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Karim, Sultan M.M.
Singapore, Singapore City
Kk Women's and Children's Hospital
Bydeman, M.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Herczeg, J.
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Statistics
Citations: 21
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/0020-7292(82)90198-9
ISSN:
00207292
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Violence And Injury
Study Design
Cohort Study