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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The interaction of de novo and pre-existing aortic regurgitation after TAVI: Insights from a new quantitative aortographic technique
EuroIntervention, Volume 13, No. 1, Year 2017
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Description
Aims: The aim of this study was to evaluate the intermediate-term clinical impact of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) using a novel quantitative angiographic method taking into account the influence of pre-existing AR. Methods and results: AR after TAVI was quantified in 338 patients (age 82 [78-86] years; 55% male) and the influence on intermediate-term all-cause mortality was evaluated. In 228 aortograms, AR was quantitated using a dedicated videodensitometric method focused in the left ventricular outflow tract (LVOT-AR). Patients with LVOT-AR >0.17 had a significantly increased all-cause mortality at three years, compared with patients who had LVOT-AR ≤0.17 (adjusted hazard ratio [HR]: 1.73, 95% confidence interval [CI]: 1.05-2.86, p=0.032). Taking the influence of pre-existing AR into account, patients with post-procedural LVOT-AR >0.17 and ≤mild pre-existing AR had a significantly increased mortality at two years, compared to patients with LVOT-AR >0.17 and >mild pre-existing AR (HR: 2.55, 95% CI: 1.16-5.58, p=0.029). In those with >mild pre-existing AR (n=70), post-TAVI LVOT-AR >0.17 was not associated with increased mortality (HR: 0.77, 95% CI: 0.31-1.91, p=0.578). Conclusions: AR after TAVI could be quantitated utilising LVOT-AR. The cut-point of >0.17 indicates a significant AR pertaining to increased intermediate-term mortality, especially in those with no significant pre-existing AR. © Europa Digital & Publishing 2017. All rights reserved.
Authors & Co-Authors
Tateishi, Hiroki
Netherlands, Rotterdam
Erasmus Mc
Abdelghani, Mohammad
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Cavalcante, Rafael
Netherlands, Rotterdam
Erasmus Mc
Miyazaki, Yosuke
Netherlands, Rotterdam
Erasmus Mc
Campos, Carlos M.
Brazil, Sao Paulo
Universidade de São Paulo
Brazil, Sao Paulo
Hospital Israelita Albert Einstein
Slots, Tristan L.B.
Netherlands, Maastricht
Pie Medical Imaging
Leite, Rogério S.
Brazil, Porto Alegre
Instituto de Cardiologia/fundacao Universitaria de Cardiologia
Mangione, José Armando
Brazil, Paraiso
Beneficenca Portuguesa Hospital Sao Paulo
Abizaid, Alexandre A.C.
Brazil, Sao Paulo
Universidade de São Paulo
Brazil, Sao Paulo
Instituto Dante Pazzanese de Cardiologia
Soliman, O. I.I.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Rotterdam
Cardialysis bv
Onuma, Yosinobu
Netherlands, Rotterdam
Erasmus Mc
Serruys, Patrick W.
United Kingdom, London
Imperial College London
Lemos, Pedro A.
Brazil, Sao Paulo
Universidade de São Paulo
de Brito, Fábio Sândoli
Brazil, Sao Paulo
Hospital Israelita Albert Einstein
Statistics
Citations: 13
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.4244/EIJ-D-16-00647
ISSN:
1774024X
Research Areas
Environmental
Study Approach
Quantitative
Participants Gender
Male