MTHFR C677T genotyping in autistic patients correlated with hyperuricemia

Autism is a complex neuro developmental disorder with a combined genetic and environmental factor. In the present study, we aimed to investigate genotyping of MTHFR C677T polymorphismin autistic patients and its correlation with Hyperuricemia. Fifty two children with autism and 27 nonautistic as a control group were included in our study.Autism patients were diagnosed by child psychiatrists according to DSM-5 criteria.Blood samples were collected during the period from December 2016 to February 2017in Baghdadcenters. Polymorphismof MTHFR C677T (rs1801133) was detected by polymerase chain reaction- restriction fragment length polymorphism. The MTHFR 677T frequency was present to be lowerin autistic children compared with non autistic (24% vs78%). The homozygous genotype CC was higher in patients with autism than the control group, while heterozygous CT genotype of the MTHFR C677T was lower in patients with autism the than control group, whereas TT genotype was higher in the control group than the autism patients. Hyperuricemia was higher in autistic patients 31(59.61%). CT genotype had greater mean uric acid levels (10.5 mg/dL) in female with autism than male(7.3 ± 0.8 mg/dL). TT genotype frequency had significantly higher mean uric acid levels (7.3 ±1.2 mg/dL) in male with autism compared to female (3.8 ± 0.3 mg/dL). Our study indicated that the MTHFR C677T polymorphism contributes to moderate predictors of autism risk. MTHFR TC genotye and hyperuricemia have been identified as risk factors for autism.