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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Dominant TNF-α
+
Mycobacterium tuberculosis-specific CD4
+
T cell responses discriminate between latent infection and active disease
Nature Medicine, Volume 17, No. 3, Year 2011
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Description
Rapid diagnosis of active Mycobacterium tuberculosis (Mtb) infection remains a clinical and laboratory challenge. We have analyzed the cytokine profile (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2)) of Mtb-specific T cells by polychromatic flow cytometry. We studied Mtb-specific CD4+ T cell responses in subjects with latent Mtb infection and active tuberculosis disease. The results showed substantial increase in the proportion of single-positive TNF-α Mtb-specific CD4+ T cells in subjects with active disease, and this parameter was the strongest predictor of diagnosis of active disease versus latent infection. We validated the use of this parameter in a cohort of 101 subjects with tuberculosis diagnosis unknown to the investigator. The sensitivity and specificity of the flow cytometry-based assay were 67% and 92%, respectively, the positive predictive value was 80% and the negative predictive value was 92.4%. Therefore, the proportion of single-positive TNF-α Mtb-specific CD4+ T cells is a new tool for the rapid diagnosis of active tuberculosis disease. © 2011 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Harari, Alexandre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Swiss Vaccine Research Institute
Rozot, Virginie
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Enders, Felicitas Bellutti
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Perreau, Matthieu
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Stalder, Jesica Mazza
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Nicod, Laurent Pierre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Cavassini, Matthias L.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Calandra, Thierry F.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Blanchet, Catherine Lazor
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Jaton, Katia
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Faouzi, Mohamed
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Day, Cheryl Cheryl L.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Bart, Pierre Alexandre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Pantaleo, Giuseppe P.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Swiss Vaccine Research Institute
Statistics
Citations: 389
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.1038/nm.2299
ISSN:
10788956
e-ISSN:
1546170X
Research Areas
Cancer
Study Design
Cohort Study