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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Chlamydia antibodies, chlamydia heat shock protein, and adverse sequelae after pelvic inflammatory disease: The PID Evaluation and Clinical Health (PEACH) Study
Sexually Transmitted Diseases, Volume 35, No. 2, Year 2008
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Description
BACKGROUND: Among women with pelvic inflammatory disease (PID), we assessed the associations among antibodies to Chlamydia trachomatis elementary bodies (EB), antibodies to chlamydia heat shock protein (Chsp60), rates of pregnancy, and PID recurrence. METHODS: Four hundred forty-three women with clinical signs and symptoms of mild to moderate PID enrolled in the PID Evaluation and Clinical Health Study were followed for a mean of 84 months for outcomes of time-to-pregnancy and time-to-PID recurrence. Antibodies to EB and Chsp60 were assessed in relation to these long-term sequelae of PID. RESULTS: Rates of pregnancy were significantly lower (adj. hazard ratio 0.47, 95% confidence interval 0.28-0.79) and PID recurrence higher (adj. hazard ratio 2.48, 95% confidence interval 1.00-6.27) after adjusting for confounding factors among women whose antibody titers to chlamydia EB measured in the final year of follow-up were in the highest tertile. CONCLUSION: Among women with mild to moderate PID, antibodies to C. trachomatis were independently associated with reduced rates of pregnancy and elevated rates of recurrent PID. © Copyright 2008 American Sexually Transmitted Diseases Association.
Authors & Co-Authors
Ness, Roberta B.
United States, Pittsburgh
University of Pittsburgh
Soper, David E.
United States, Charleston
Medical University of South Carolina
Richter, Holly Elizabeth
United States, Birmingham
Heersink School of Medicine
Nelson, Deborah Brooks
United States, Philadelphia
University of Pennsylvania
Brunham, Robert C.
Canada, Vancouver
University of British Columbia, Faculty of Medicine
Statistics
Citations: 67
Authors: 5
Affiliations: 10
Identifiers
Doi:
10.1097/OLQ.0b013e3181557c25
ISSN:
01485717
Research Areas
Environmental
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female