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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
An overview of occult hepatitis B virus infection
World Journal of Gastroenterology, Volume 17, No. 15, Year 2011
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Description
Occult hepatitis B virus (HBV) infection (OBI), alternatively defined as occult hepatitis B (OHB), is a challenging clinical entity. It is recognized by two main characteristics: absence of HBsAg, and low viral replication. The previous two decades have witnessed a remarkable progress in our understanding of OBI and its clinical implications. Appropriate diagnostic techniques must be adopted. Sensitive HBV DNA amplification assay is the gold standard assay for detection of OBI. Viral as well as host factors are implicated in the pathogenesis of OBI. However, published data reporting the infectivity of OBI by transfusion are limited. Several aspects including OBI transmission, infectivity and its relation to the development of chronic liver diseases and hepatocellular carcinoma have to be resolved. The aim of the present review is to highlight recent data on OBI with a focus on its virological diagnosis and clinical outcome. © 2011 Baishideng. All rights reserved.
Authors & Co-Authors
Said, Zeinab N.
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 172
Authors: 1
Affiliations: 1
Identifiers
Doi:
10.3748/wjg.v17.i15.1927
ISSN:
10079327
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases