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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Response to combination antiretroviral therapy: Variation by age
AIDS, Volume 22, No. 12, Year 2008
Notification
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Description
Objective: To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons. Design and Setting: Multicohort collaboration of 33 European cohorts. Subjects: Forty-nine thousand nine hundred and twenty-one antiretroviral-naive individuals starting combination antiretroviral therapy from 1998 to 2006. Outcome Measures: Time from combination antiretroviral therapy initiation to HIV RNA less than 50 copies/ml (virological response), CD4 increase of more than 100 cells/μl (immunological response) and new AIDS/death were analysed using survival methods. Ten age strata were chosen: less than 2, 2-5, 6-12, 13-17, 18-29, 30-39 (reference group), 40-49, 50-54, 55-59 and 60 years or older; those aged 6 years or more were included in multivariable analyses. Results: The four youngest age groups had 223, 184, 219 and 201 individuals and the three oldest age groups had 2693, 1656 and 1613 individuals. Precombination antiretroviral therapy CD4 cell counts were highest in young children and declined with age. By 12 months, 53.7% (95% confidence interval: 53.2-54.1%) and 59.2% (58.7-59.6%) had experienced a virological and immunological response. The probability of virological response was lower in those aged 6-12 (adjusted hazard ratio: 0.87) and 13-17 (0.78) years, but was higher in those aged 50-54 (1.24), 55-59 (1.24) and at least 60 (1.18) years. The probability of immunological response was higher in children and younger adults and reduced in those 60 years or older. Those aged 55-59 and 60 years or older had poorer clinical outcomes after adjusting for the latest CD4 cell count. Conclusion: Better virological responses but poorer immunological responses in older individuals, together with low precombination antiretroviral therapy CD4 cell counts, may place this group at increased clinical risk. The poorer virological responses in children may increase the likelihood of emergence of resistance. © 2008 Wolters Kluwer Health / Lippincott Williams & Wilkins.
Authors & Co-Authors
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Smith, Colette Joanne
Unknown Affiliation
D'Arminio Monforte, Antonella D.
Unknown Affiliation
Galli, Luisa
Unknown Affiliation
Geelen, Sibyl P.M.
Unknown Affiliation
Gibb, Di M.
Unknown Affiliation
Guiguet, Marguerite
Unknown Affiliation
Judd, Ali M.
Unknown Affiliation
Leport, Catherine
Unknown Affiliation
Dabis, François
Unknown Affiliation
Pantazis, Nikos
Unknown Affiliation
Porter, Kholoud
Unknown Affiliation
Raffi, François
Unknown Affiliation
Thorne, Claire N.
Unknown Affiliation
Torti, Carlo
Unknown Affiliation
Walker, Sarah A.S.
Unknown Affiliation
Warszawski, Josiane
Unknown Affiliation
Wintergerst, Uwe
Unknown Affiliation
Chêne, Geneviève
Unknown Affiliation
Weller, Ian V.D.
Unknown Affiliation
Costagliola, Dominique
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Touloumi, Giota
Unknown Affiliation
Meyer, Laurence J.
Unknown Affiliation
Krause, Murielle Mary
Unknown Affiliation
Goujard, Cécile D.Sign©cile
Unknown Affiliation
Reiss, Peter
Unknown Affiliation
Porter, Kholoud
Unknown Affiliation
Dorrucci, Maria
Unknown Affiliation
Sabin, Caroline A.
Unknown Affiliation
del Amo, Julia
Unknown Affiliation
Obel, Niels
Unknown Affiliation
Mocroft, Amanda J.
Unknown Affiliation
Staszewski, Schlomo
Unknown Affiliation
Almeda Ortega, Jesús
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Tovo, P.
Unknown Affiliation
Salzberger, Bernd
Unknown Affiliation
Fätkenheuer, Gerd
Unknown Affiliation
Ramos, José Tomás
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Tookey, Pat A.
Unknown Affiliation
Casabona, Jordi
Unknown Affiliation
Miró, José María ª.
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
de Wit, Stéphane
Unknown Affiliation
Teira, Ramón M.
Unknown Affiliation
Garrido, Myriam
Unknown Affiliation
Dedes, Nikos
Unknown Affiliation
Phillips, Andrew N.
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Newell, Marie Louise
Unknown Affiliation
Sterne, Jonathan A.C.
Unknown Affiliation
Telenti, Amalio
Unknown Affiliation
Statistics
Citations: 229
Authors: 55
Affiliations: 1
Identifiers
Doi:
10.1097/QAD.0b013e3282f88d02
ISSN:
02699370
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study