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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Developing a SNP panel for forensic identification of individuals
Forensic Science International, Volume 164, No. 1, Year 2006
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Description
Single nucleotide polymorphisms (SNPs) are likely in the near future to have a fundamental role in forensics in both human identification and description. However, considerable research is necessary to establish adequate scientific foundations for these applications. In the case of identification, because allele frequencies can vary greatly among populations, the population genetics of match probabilities is a critical issue. Some SNPs, however, show little allele frequency variation among populations while remaining highly informative. We describe here both an efficient strategy for identifying and characterizing such SNPs, and test that strategy on a broad representation of world populations. Markers with high heterozygosity and little frequency variation among African American, European American, and East Asian populations are selected for additional screening on seven populations that provide a sampling of genetic variation from the world's major geographical regions. Those with little allele frequency variation on the seven populations are then screened on a total of 40 populations (∼2100 individuals) and the most promising retained. The preliminary panel of 19 SNPs, from an initial selection of 195 SNPs, gives an average match probability of <10-7 in most of 40 populations studied and no greater than 10-6 in the most isolated, inbred populations. Expansion of this panel to ∼50 comparable SNPs should give match probabilities of about 10-15 with a small global range. © 2005 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Kidd, Kenneth K.
United States, New Haven
Yale School of Medicine
Pakstis, Andrew J.
United States, New Haven
Yale School of Medicine
Speed, William C.
United States, New Haven
Yale School of Medicine
Grigorenko, Elena L.
United States, New Haven
Yale Child Study Center
Kajuna, Sylvester L.B.
Tanzania, Dar es Salaam
Hubert Kairuki Memorial University
Karoma, Nganyirwa J.
Tanzania, Dar es Salaam
Hubert Kairuki Memorial University
Kungulilo, Selemani
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Kim, Jong Jin
South Korea, Seoul
National Institute of Scientific Investigation
Lu, Ru-Band Band
Taiwan, Tainan
National Cheng Kung University College of Medicine
Odunsi, Adekunle O.
United States, Buffalo
Roswell Park Cancer Institute
Okonofua, Friday Ebhodaghe
Nigeria, Benin
University of Benin
Párnas, Josef
Denmark, Copenhagen
Københavns Universitet
Schulz, Leslie O.
United States, El Paso
The University of Texas at el Paso
Zhukova, Olga V.
Russian Federation, Moscow
Russian Academy of Sciences
Kidd, Judith R.
United States, New Haven
Yale School of Medicine
Statistics
Citations: 218
Authors: 15
Affiliations: 11
Identifiers
Doi:
10.1016/j.forsciint.2005.11.017
ISSN:
03790738
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study