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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Brain white matter damage in aging and cognitive ability in youth and older age
Neurobiology of Aging, Volume 34, No. 12, Year 2013
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Description
Cerebral white matter hyperintensities (WMH) reflect accumulating white matter damage with aging and impair cognition. The role of childhood intelligence is rarely considered in associations between cognitive impairment and WMH. We studied community-dwelling older people all born in 1936, in whom IQ had been assessed at age 11 years. We assessed medical histories, current cognitive ability and quantified WMH on MR imaging. Among 634 participants, mean age 72.7 (SD 0.7), age 11 IQ was the strongest predictor of late life cognitive ability. After accounting for age 11 IQ, greater WMH load was significantly associated with lower late life general cognitive ability (β=-0.14, p < 0.01) and processing speed (β=-0.19, p < 0.001). WMH were also associated independently with lower age 11 IQ (β=-0.08, p < 0.05) and hypertension. In conclusion, having more WMH is significantly associated with lower cognitive ability, after accounting for prior ability, age 11IQ. Early-life IQ also influenced WMH in later life. Determining how lower IQ in youth leads to increasing brain damage with aging is important for future successful cognitive aging. © 2013 The Authors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3898072/bin/mmc1.doc
Authors & Co-Authors
Valdés-Hernández, Maria Del Carmen
United Kingdom, Edinburgh
The University of Edinburgh
Booth, Tom W.
United Kingdom, Edinburgh
The University of Edinburgh
Murray, Catherine
United Kingdom, Edinburgh
The University of Edinburgh
Gow, Alan J.
United Kingdom, Edinburgh
Heriot-watt University
Penke, Lars
United Kingdom, Edinburgh
The University of Edinburgh
Morris, Zoe
United Kingdom, Edinburgh
The University of Edinburgh
Muñoz Maniega, Susana
United Kingdom, Edinburgh
The University of Edinburgh
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
Aribisala, Benjamin Segun
Nigeria, Lagos
Lagos State University
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
Starr, John M.
United Kingdom, Edinburgh
The University of Edinburgh
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 94
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/j.neurobiolaging.2013.05.032
e-ISSN:
15581497
Research Areas
Maternal And Child Health
Noncommunicable Diseases