Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Linkage analysis of 7 polymorphic markers at chromosome 11p11. 2‐11q13 in 27 multiple endocrine neoplasia type 1 families
Annals of Human Genetics, Volume 57, No. 1, Year 1993
Notification
URL copied to clipboard!
Description
The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localized to llq13 by combined tumour deletion mapping and linkage studies. Family linkage analysis has defined the locus order as 11cen‐PGA‐(PYGM, MENl)‐(D11S197, D11S146)‐INT2‐11qter, and tumour deletion mapping studies have suggested that the MEN1 locus is proximal to D11S146 but distal to PYGM. In order to establish further the location of MEN1, we have utilized the seven polymorphic DNA probes: D118S88, D11S149, PGA, PYGM, D11S97, D11S146 and INT2, in linkage studies of 339 members (116 affected) from 27 MEN 1 families. Linkage between MEN 1 and 6 of the 7 loci was established, and the highest peak lod scores [Z(θ)] were observed with PYGM and D11S97 at Z(θ) = 13–71, θ= 0.047 and Z(θ) = 13.76, θ= 0.076 respectively. Multilocus analysis suggested the most likely locus order as:11pter‐(D11S288, D11S149)‐11cen‐PGA‐PYGM‐MEN1‐D11S97‐D11S146‐INT2‐11qter. In addition, an examination of individual recombinants indicated a centromeric location of D11S149 in relation to D115288. Thus, the results of our study, which favoured a location of MEN1 proximal to D11S97 and distal to PYGM, have established a panel of recombinants that will facilitate further meiotic mapping studies of the MEN 1 locus. Copyright © 1993, Wiley Blackwell. All rights reserved
Authors & Co-Authors
THAKKER, R. V.
United Kingdom, London
Mrc Clinical Research Centre
WOODING, C.
United Kingdom, London
Mrc Clinical Research Centre
PANG, J. T.
United Kingdom, London
Mrc Clinical Research Centre
FARREN, B.
United Kingdom, London
Mrc Clinical Research Centre
HARDING, B.
United Kingdom, London
Mrc Clinical Research Centre
ANDERSON, D. C.
United Kingdom, Salford
Salford Royal Hospital
BESSER, G. M.
United Kingdom, London
St Bartholomew's Hospital
BOULOUX, P.
United Kingdom, London
St Bartholomew's Hospital
BRENTON, D. P.
United Kingdom, London
University College Hospital
Buchanan, Keith Deans
United Kingdom, Belfast
Royal Victoria Hospital Belfast
EDWARDS, C. R.
United Kingdom, Edinburgh
Western General Hospital
HEATH, D. A.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Jackson, Charles Eugene
United States, Detroit
Henry Ford Hospital
Jansen, Stander
South Africa, Bloemfontein
University of the Free State
LIPS, K.
Netherlands, Utrecht
University Medical Center Utrecht
NORUM, R. A.
United States, Detroit
Henry Ford Hospital
Sampson, Julian R.
United Kingdom, Cardiff
University Hospital of Wales
Shalet, Stephen Michael
United Kingdom, Manchester
Charistie Hospital
TARGGART, R. T.
United States, Detroit
Wayne State University
TAILOR, D.
United Kingdom, London
Mrc Clinical Research Centre
WHEELER, M. H.
United Kingdom, Cardiff
Cardiff Royal Infirmary
WOOLLARD, P. M.
United Kingdom, London
Mrc Clinical Research Centre
YATERS, J.
United Kingdom, Cambridge
Addenbrooke's Hospital
Statistics
Citations: 29
Authors: 23
Affiliations: 15
Identifiers
Doi:
10.1111/j.1469-1809.1993.tb00883.x
e-ISSN:
14691809
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Male