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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): Their effects on three selected glycolytic enzymes of Trypanosoma brucei
Bioorganic and Medicinal Chemistry Letters, Volume 20, No. 12, Year 2010
Notification
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Description
In continuation of our study on medicinal plants of Cameroon, stem barks of Polyalthia suaveolens were phytochemically studied. This investigation yielded a new indolosesquiterpene alkaloid, named polysin (1) and four hitherto known alkaloids (2-5). Polysin (1) appeared as a competitive reversible inhibitor (Ki = 10 μM) of phosphofructo kinase (PFK) of Trypanosoma brucei with respect to fructose-6-phosphate (Ki/KM = 0.05) and could be used in the design of new trypanocidal drugs. The other isolated compounds (2-5) also exhibited interesting inhibitory effects on selected glycolytic enzymes (PFK, glyceraldehyde-3-phosphate dehydrogenase and aldolase). © 2010 Published by Elsevier Ltd.
Authors & Co-Authors
Ngantchou, Igor Eric W.
Cameroon, Yaounde
Université de Yaoundé I
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Nyassé, Barthélémy
Cameroon, Yaounde
Université de Yaoundé I
Denier, Colette J.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Blonski, Casimir
France, Toulouse
Université Toulouse Iii - Paul Sabatier
France, Orsay
Institut de Chimie Moléculaire et Des Matériaux D'orsay
Hannaert, Véronique
Belgium, Brussels
De Duve Institute
Schneider, Bernd
Germany, Jena
Max Planck Institute for Chemical Ecology
Statistics
Citations: 66
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.bmcl.2010.04.145
ISSN:
0960894X
Study Locations
Cameroon