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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
1,5-Diphenylpent-3-en-1-ynes and methyl naphthalene carboxylates from Lawsonia inermis and their anti-inflammatory activity
Phytochemistry, Volume 88, Year 2013
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Description
Lawsonia inermis (Lythraceae) known as henna is one of the most popular and ancient plants used in cosmetics and hair dying. It is cultivated for its leaves but other parts such as seeds, flowers, stem bark and roots are also used in traditional medicine for millennia. Henna tattoo paste also proved to be beneficial for wound healing and in several skin diseases suggesting potent anti-inflammatory activity. To evaluate henna anti-inflammatory activity, 31 compounds, including three 1,5-diphenylpent-3-en-1-yne derivatives, lawsochylin A-C and three methyl naphthalene carboxylates, lawsonaphthoate A-C, were isolated from the stems and leaves of henna utilizing a bioassay-guided fractionation. The structures of the compounds were elucidated by spectroscopic data. Two compounds, lawsochylin A and lawsonaphthoate A showed potent anti-inflammatory activity by inhibition of superoxide anion generation (IC 50 = 1.80 and 1.90 μg/ml) and elastase release (IC50 = 1.58 and 3.17 μg/ml) of human neutrophils in response to fMLP or cytochalasin B. Moreover, the known compounds, luteolin, apigenin, 4S-4-hydroxy-α- tetralone, and 2-butoxysuccinic acid, also showed potent inhibition of superoxide anion generation (IC50 = 0.75-1.78 μg/ml) and elastase release (IC50 = 1.62-3.61 μg/ml). © 2013 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Liou, Jingru
Taiwan, Kaohsiung
Kaohsiung Medical University
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Du, Yingchi
Taiwan, Kaohsiung
Kaohsiung Medical University
Tseng, Chao Neng
Taiwan, Kaohsiung
Kaohsiung Medical University
Hwang, Tsong Long
Taiwan, Taoyuan
Chang Gung University College of Medicine
Chuang, Yueh Lin
Taiwan, Kaohsiung
Kaohsiung Medical University
Hsu, Yuming
Taiwan, Kaohsiung
Kaohsiung Medical University
Hsieh, Pei Wen
Taiwan, Taoyuan
Chang Gung University College of Medicine
Wu, Chinchung
Taiwan, Kaohsiung
Kaohsiung Medical University
Chen, Shuli
Taiwan, Kaohsiung
Kaohsiung Medical University
Hou, Mingfeng
Taiwan, Kaohsiung
College of Medicine
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Taiwan, Kaohsiung
National Sun Yat-sen University
Wu, Yangchang
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Taichung
China Medical University Hospital
Taiwan, Taichung
China Medical University College of Medicine
Statistics
Citations: 57
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1016/j.phytochem.2012.11.010
ISSN:
00319422
Research Areas
Health System And Policy