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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Evolutionary history of helicobacter pylori sequences reflect past human migrations in southeast Asia
PLoS ONE, Volume 6, No. 7, Article e22058, Year 2011
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Description
The human population history in Southeast Asia was shaped by numerous migrations and population expansions. Their reconstruction based on archaeological, linguistic or human genetic data is often hampered by the limited number of informative polymorphisms in classical human genetic markers, such as the hypervariable regions of the mitochondrial DNA. Here, we analyse housekeeping gene sequences of the human stomach bacterium Helicobacter pylori from various countries in Southeast Asia and we provide evidence that H. pylori accompanied at least three ancient human migrations into this area: i) a migration from India introducing hpEurope bacteria into Thailand, Cambodia and Malaysia; ii) a migration of the ancestors of Austro-Asiatic speaking people into Vietnam and Cambodia carrying hspEAsia bacteria; and iii) a migration of the ancestors of the Thai people from Southern China into Thailand carrying H. pylori of population hpAsia2. Moreover, the H. pylori sequences reflect iv) the migrations of Chinese to Thailand and Malaysia within the last 200 years spreading hspEasia strains, and v) migrations of Indians to Malaysia within the last 200 years distributing both hpAsia2 and hpEurope bacteria. The distribution of the bacterial populations seems to strongly influence the incidence of gastric cancer as countries with predominantly hspEAsia isolates exhibit a high incidence of gastric cancer while the incidence is low in countries with a high proportion of hpAsia2 or hpEurope strains. In the future, the host range expansion of hpEurope strains among Asian populations, combined with human motility, may have a significant impact on gastric cancer incidence in Asia. © 2011 Breurec et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3139604/bin/pone.0022058.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3139604/bin/pone.0022058.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3139604/bin/pone.0022058.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3139604/bin/pone.0022058.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3139604/bin/pone.0022058.s005.doc
Authors & Co-Authors
Breurec, Sébastien
Senegal, Dakar
Institut Pasteur de Dakar
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Guillard, Bertrand
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Hem, Sopheak
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Brisse, Sylvain
France, Paris
Institut Pasteur, Paris
Dieye, Fatou Bintou
Senegal, Dakar
Institut Pasteur de Dakar
Huerre, Michel René
France, Paris
Institut Pasteur, Paris
Oung, Chakravuth
Cambodia, Phnom Penh
Calmette Hospital
Raymond, Josette
France, Paris
Institut Pasteur, Paris
France, Paris
Université Paris Cité
Tan, Tek Sreng
Cambodia, Phnom Penh
Private Medical Center
Thiberge, Jean Michel
France, Paris
Institut Pasteur, Paris
Vong, Sirenda
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Monchy, Didier
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Central African Republic, Bangui
Institut Pasteur de Bangui
Linz, Bodo
United States, University Park
Pennsylvania State University
Statistics
Citations: 57
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0022058
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study