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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
International collaborative study on ghost cell odontogenic tumours: Calcifying cystic odontogenic tumour, dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma
Journal of Oral Pathology and Medicine, Volume 37, No. 5, Year 2008
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Description
Background: Calcifying odontogenic cyst was described first by Gorlin et al. in 1962; since then several hundreds of cases had been reported. In 1981, Prætorius et al. proposed a widely used classification. Afterwards, several authors proposed different classifications and discussed its neoplastic potential. The 2005 WHO Classification of Odontogenic Tumours re-named this entity as calcifying cystic odontogenic tumour (CCOT) and defined the clinico-pathological features of the ghost cell odontogenic tumours, the CCOT, the dentinogenic ghost cell tumour (DGCT) and the ghost cell odontogenic carcinoma (GCOC). Methods: The aim of this paper was to review the clinical-pathological features of 122 CCOT, DGCT and GCOC cases retrieved from the files of the oral pathology laboratories from 14 institutions in Mexico, South Africa, Denmark, the USA, Brazil, Guatemala and Peru. It attempts to clarify and to group the clinico-pathological features of the analysed cases and to propose an objective, comprehensive and useful classification under the 2005 WHO classification guidelines. Results: CCOT cases were divided into four sub-types: (i) simple cystic; (ii) odontoma associated; (iii) ameloblastomatous proliferating; and (iv) CCOT associated with benign odontogenic tumours other than odontomas. DGCT was separated into a central aggressive DGCT and a peripheral non-aggressive counterpart. For GCOC, three variants were identified. The first reported cases of a recurrent peripheral CCOT and a multiple synchronous, CCOT are included. Conclusions: Our results suggest that ghost cell odontogenic tumours comprise a heterogeneous group of neoplasms which need further studies to define more precisely their biological behaviour. © 2008 The Authors.
Authors & Co-Authors
Ledesma-Montes, Constantino
Mexico, Mexico
Universidad Nacional Autónoma de México
Gorlin, Robert James
United States, Minneapolis
University of Minnesota Twin Cities
Shear, Mervyn
South Africa, Bellville
University of the Western Cape
Prǽtorius, Finn
Denmark, Copenhagen
Tandlægeskolen
Mosqueda-Taylor, Adalberto
Mexico, Mexico
Universidad Autónoma Metropolitana Unidad Xochimilco
Altini, Mario
South Africa, Johannesburg
University of the Witwatersrand
Unni, K. Krishnan
United States, Rochester
Mayo Clinic
Almeida, Oslei Paes de
Brazil, Campinas
Universidade Estadual de Campinas
Carlos-Bregni, Román
Guatemala, Guatemala City
Centro Clínico de Cabeza y Cuello
Romero De León, Elías
Mexico, Monterrey
Universidad Autóonoma de Nuevo León
Phillips, Vincent M.
South Africa, Stellenbosch
Stellenbosch University
Delgado-Azañero, Wilson Alejandro
Peru, Lima
Universidad Peruana Cayetano Heredia
Meneses-García, Abelardo A.
Mexico, Tlalpan
Instituto Nacional de Cancerologia, México
Statistics
Citations: 182
Authors: 13
Affiliations: 13
Identifiers
Doi:
10.1111/j.1600-0714.2007.00623.x
ISSN:
09042512
e-ISSN:
16000714
Research Areas
Cancer
Health System And Policy
Study Locations
South Africa