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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predominance of heart failure in the heart of Soweto study cohort: Emerging challenges for urban African communities
Circulation, Volume 118, No. 23, Year 2008
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Description
There is a paucity of data to describe the clinical characteristics of heart failure (HF) in urban African communities in epidemiological transition. Methods and Results - Chris Hani Baragwanath Hospital services the 1.1 million black African community of Soweto. South Africa. Of 1960 cases of HF and related cardiomyopathies in 2006, we prospectively collected detailed demographic and clinical data from all 844 de novo presentations (43%). Mean age was 55 ± 16 years, and women (479 [57%]) and black Africans (739 [88%]) predominated. Most (761 [90%]) had ≥1 cardiovascular risk. Mean left ventricular ejection fraction was 45 ± 18%. Overall, 180 patients (23%) had isolated diastolic dysfunction, 234 (28%) tricuspid regurgitation, 121 (14%) isolated right HF, and 100 (12%) mitral regurgitation. The most common diagnoses were hypertensive HF (281 [33%]), idiopathic dilated cardiomyopathy (237 [28%]), and, surprisingly, right HF (225 [27%]). Black Africans had less ischemic cardiomyopathy (adjusted odds ratio, 0.12; 95% CI, 0.07 to 0.20) but more idiopathic and other causes of cardiomyopathy (adjusted odds ratio, 4.80; 95% CI, 2.57 to 8.93). Concurrent renal dysfunction, anemia, and atrial fibrillation were found in 172 (25%), 72 (10%), and 53 (6.3%) cases, respectively. Conclusions - These contemporary data highlight the multiple challenges of preventing and managing an increasing and complex burden of HF in urban Africa. In addition to tackling antecedent hypertension, a predominance of young women and a large component of right HF predicate the development of tailored therapeutic strategies. © 2008 American Heart Association, Inc.
Authors & Co-Authors
Stewart, Simon D.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Australia, Melbourne
Baker Heart and Diabetes Institute
Wilkinson, David D.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Australia, Brisbane
The University of Queensland
Hansen, Craig A.
Australia, Brisbane
The University of Queensland
Vaghela, Vinesh
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Mvungi, Robert
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
McMurray, John JV
United Kingdom, Glasgow
University of Glasgow
Sliwa, Karen S.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Statistics
Citations: 216
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1161/CIRCULATIONAHA.108.786244
ISSN:
00097322
e-ISSN:
15244539
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study
Study Locations
South Africa
Participants Gender
Female