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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Metabolic syndrome components are associated with symptomatic polyneuropathy independent of glycemic status
Diabetes Care, Volume 39, No. 5, Year 2016
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Description
OBJECTIVE: Previous studies demonstrate that the metabolic syndrome is associated with distal symmetric polyneuropathy (DSP). We aimed to determine the magnitude of this effect and the precise components involved. RESEARCH DESIGN AND METHODS: We determined the symptomatic DSP prevalence in the Health, Aging, and Body Composition (Health ABC) study (prospective cohort study, with subjects aged 70-79 years at baseline), stratified by glycemic status (glucose tolerance test) and the number of additional metabolic syndrome components (updated National Cholesterol Education Program/AdultTreatment Panel III definition). DSP wasdefined as neuropathic symptoms (questionnaire) plus at least one of three confirmatory tests (heavy monofilament, peroneal conduction velocity, and vibration threshold). Multivariable logistic and linear regression evaluated the association of metabolic syndrome components with DSP in cross-sectional and longitudinal analyses. RESULTS: Of 2,382 participants with neuropathy measures (mean age 73.5 ± 2.9 years, 38.2% black, 51.7% women), 21.0% had diabetes, 29.9% prediabetes, 52.8% metabolic syndrome, and 11.1% DSP. Stratified by glycemic status, DSP prevalence increased as the number of metabolic syndrome components increased (P = 0.03). Diabetes (cross-sectional model, odds ratio [OR] 1.65 [95% CI 1.18-2.31]) and baseline hemoglobin A1C (longitudinal model, OR 1.42 [95% CI 1.15-1.75]) were the only metabolic syndrome measures significantly associated with DSP. Waist circumference and HDL were significantly associated with multiple secondary neuropathy outcomes. CONCLUSIONS: Independent of glycemic status, symptomatic DSP is more common in those with additional metabolic syndrome components. However, the issue of which metabolic syndrome components drive this association, in addition to hyperglycemia, remains unclear. Larger waist circumference and low HDL may be associated with DSP, but larger studies with more precise metabolic measures are needed. © 2016 by the American Diabetes Association.
Authors & Co-Authors
Callaghan, Brian C.
United States, Ann Arbor
University of Michigan, Ann Arbor
Banerjee, Mousumi M.
United States, Ann Arbor
University of Michigan, Ann Arbor
de Rekeneire, Nathalie
France, Bordeaux
Bordeaux Population Health Research Center Bph
Harris, Tamara B.
United States, Bethesda
National Institute on Aging Nia
Newman, Anne B.
United States, Pittsburgh
University of Pittsburgh
Schwartz, Ann V.
United States, San Francisco
University of California, San Francisco
Vinik, Aaron I.
Unknown Affiliation
Strotmeyer, Elsa S.
United States, Pittsburgh
University of Pittsburgh
Statistics
Citations: 130
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.2337/dc16-0081
ISSN:
01495992
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative
Participants Gender
Female