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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.
Phytochemistry, Volume 67, No. 3, Year 2006
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Description
A xanthone derivative, named gaboxanthone (1), has been isolated from the seed shells of Symphonia globulifera, together with known compounds, symphonin (2), globuliferin (3), guttiferone A (4), sistosterol, oleanolic acid and methyl citrate. The structure of the compound was assigned as 5,10-dihydroxy-8,9- dimethoxy-2,2-dimethyl-12-(3-methylbut-2-enyl) pyrano [3,2-b]xanthen-6(2H)-one, by means of spectroscopic analysis. The anti-plasmodial and antioxidant activities of the phenolic compounds were evaluated, respectively, in culture against W2 strain of Plasmodium falciparum and using the free radical scavenging activity of the DPPH radical, respectively. Compounds 1-4 were found to be active against the Plasmodium parasites (IC50 of 3.53, 1.29, 3.86 and 3.17 μM, respectively). Guttiferone A (4) showed a potent free radical scavenging activity compared to the well-known antioxidant caffeic acid. © 2005 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Ngouéla, Silvère Augustin
Cameroon, Yaounde
Université de Yaoundé I
Lenta, Bruno Ndjakou
Cameroon, Yaounde
Université de Yaoundé I
Noungoué, Didérot Tchamo
Cameroon, Yaounde
Université de Yaoundé I
Ngoupayo, Joseph
Cameroon, Yaounde
Université de Yaoundé I
Boyom, Fabrice Fekam
Cameroon, Yaounde
Université de Yaoundé I
Tsamo, Etienne
Cameroon, Yaounde
Université de Yaoundé I
Gut, Jiří
United States, San Francisco
Ucsf School of Medicine
Rosenthal, Philip Jon
United States, San Francisco
Ucsf School of Medicine
Connolly, Joseph Donald
United Kingdom, Glasgow
The University
Statistics
Citations: 79
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.phytochem.2005.11.004
ISSN:
00319422