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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Arachidonic acid ω-hydroxylase CYP4A11: Inter-ethnic variations in the 8590T>C loss-of-function variant
Molecular Biology Reports, Volume 39, No. 2, Year 2012
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Description
The human Cytochrome P450 4A11 (CYP4A11) is a major x-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). Previous studies have reported a significant association between the 8590T>C genetic variant of CYP4A11 and hypertension. Interestingly, several population-based studies have reported ethnic differences in the prevalence of hypertension, with the highest prevalence in African populations. The aim of this work was to determine the frequency and inter-ethnic comparison of the CYP4A11 (8590T>C) functional polymorphism, in five new ethnic groups: European (99 French Caucasians), African (36 Gabonese and 50 Senegalese), South American (60 Peruvians) and North African (53 Tunisians) populations, using polymerase chain reaction-single strand conformational polymorphism and sequencing strategies. We confirmed that the CYP4A11 (8590T>C) functional polymorphism exhibits inter-ethnic frequency differences. Noteworthy, the highest 8590C allele frequency was observed in the Tunisian (30.2%), followed by Senegalese (20%) populations. In addition, the CC genotype was only found in the Gabonese and Tunisian populations (5.6% and 8.4%, respectively). These populations may be of major interest to help to clarify the linkage between hypertension and CYP4A11 (8590T>C) genotype in African populations. These findings provide data for further studies that investigate the potential association of CYP4A11 (8590T>C) variant with an incidence of hypertension genesis in respect of ethnicity. © 2011 Springer Science+Business Media B.V.
Authors & Co-Authors
Lino Cardenas, Christian Lacks
France, Lille
Impact de L'environnement Chimique Sur la Santé Humaine Impecs
Devos, Aurore
France, Lille
Impact de L'environnement Chimique Sur la Santé Humaine Impecs
Touré, Aminata
Senegal, Dakar
Centre Antipoison de Dakar-sénégal
Garcia, Jaime Cardenas
Peru, Arequipa
Universidad Católica de Santa María
Kénani, Abderraouf
Tunisia, Monastir
Faculté de Médecine de Monastir
Migot-Nabias, Florence
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Broly, Franck
France, Lille
Impact de L'environnement Chimique Sur la Santé Humaine Impecs
Chevalier, Dany
France, Lille
Impact de L'environnement Chimique Sur la Santé Humaine Impecs
Statistics
Citations: 8
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1007/s11033-011-0888-x
ISSN:
03014851
e-ISSN:
15734978
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study