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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: A prospective European Group for Blood and Marrow Transplantation Pediatric Diseases Working Party study
Blood, Volume 119, No. 12, Year 2012
Notification
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Description
We investigated prospectively factors influencing the safety of hematopoietic stem cell (HSC) collection in 453 pediatric donors. The children in the study donated either BM or peripheral blood stem cells (PBSCs) according to center policy. A large variability in approach to donor issues was observed between the participating centers. Significant differences were observed between BM and PBSC donors regarding pain, blood allotransfusion, duration of hospital stay, and iron supplementation; however, differences between the groups undergoing BM vs PBSC donation preclude direct risk comparisons between the 2 procedures. The most common adverse event was pain, reported mainly by older children after BM harvest, but also observed after central venous catheter (CVC) placement for PBSC collection. With regard to severe adverse events, one patient (0.7%) developed a pneumothorax with hydrothorax after CVC placement for PBSC collection. The risk of allotransfusion after BM harvest was associated with a donor age of < 4 years and a BM harvest volume of > 20 mL/kg. Children < 4 years were at higher risk than older children for allotransfusion after BM harvest and there was a higher risk of complications from CVC placement before apheresis.We conclude that PBSC and BM collection are safe procedures in children. © 2012 by The American Society of Hematology.
Authors & Co-Authors
Styczyński, Jan
Poland, Bydgoszcz
Ludwik Rydygier Collegium Medicum in Bydgoszcz
Balduzzi, Adriana C.
Italy, Monza
Dipartimento Di Medicina e Chirurgia
Gil, Lidia A.
Poland, Poznan
Poznan University of Medical Sciences
Labopin, Myriam
France, Paris
Sorbonne Université
Hamladji, Rose Marie
Algeria, Algiers
Centre Pierre et Marie Curie
Marktel, Sarah
Italy, Milan
Irccs Ospedale San Raffaele
Yeşilipek, Mehmet Akif M.
Turkey, Antalya
Akdeniz Üniversitesi
Fagioli, Franca
Italy, Turin
Ospedale Infantile Regina Margherita
Ehlert, Karoline
Germany, Munster
Universitätsklinikum Münster
Matulova, Martina
Czech Republic, Prague
Fakultní Nemocnice V Motole
Dalle, Jean Hugues H.
France, Paris
Hôpital Robert-debré Ap-hp
Wachowiak, Jacek Tadeusz
Poland, Poznan
Poznan University of Medical Sciences
Miano, Maurizio
Italy, Genoa
Istituto Giannina Gaslini
Messina, Chiara
Italy, Padua
Università Degli Studi Di Padova
Ángel Díaz, Miguel Ángel D.
Spain, Madrid
Hospital Infantil Universitario Niño Jesús
Vermylen, Christiane G.
Belgium, Brussels
Cliniques Universitaires Saint-luc
Matthias, Eyrich
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Badell, Isabel S.
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Dreger, Peter
Germany, Heidelberg
Universitätsklinikum Heidelberg
Goździk, Jolanta
Poland, Krakow
Uniwersytecki Szpital Dziecięcy w Krakowie
Hutt, Daphna
Israel, Tel Aviv-yafo
Edmond and Lily Safra Children's Hospital
Rascon, Jelena
Lithuania, Vilnius
Vilniaus Universitetas
Dini, Giorgio
Italy, Genoa
Istituto Giannina Gaslini
Peters, Christina
Austria, Vienna
St Anna Kinderspital, Vienna
Statistics
Citations: 80
Authors: 24
Affiliations: 22
Identifiers
Doi:
10.1182/blood-2011-04-349688
ISSN:
00064971
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study