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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Meta-analysis and dose-response metaregression: Circulating Insulin-Like Growth Factor I (IGF-I) and mortality
Journal of Clinical Endocrinology and Metabolism, Volume 96, No. 9, Year 2011
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Description
Context: IGF-I playsacentral role in metabolismandgrowthregulation.HighIGF- I levels are associated with increased cancer risk and low IGF-I levels with increased risk for cardiovascular disease. Objective: Our objective was to determine the relationship between circulating IGF-I levels and mortality in the general population using random-effects meta-analysis and dose-response metaregression. Data Sources: We searched PubMed, EMBASE, Web of Science, and Cochrane Library from 1985 to September 2010 to identify relevant studies. Study Selection: Population-based cohort studies and (nested) case-control studies reporting on the relation between circulating IGF-I and mortality were assessed for eligibility. Data Extraction: Data extraction was performed by two investigators independently, using a standardized data extraction sheet. Data Synthesis: Twelve studies, with 14,906 participants, were included. Overall, risk of bias was limited. Mortality in subjects with low or high IGF-I levels was compared with mid-centile reference categories. All-cause mortality was increased in subjects with low as well as high IGF-I, with a hazard ratio(HR)of1.27(95%CI=1.08-1.49)andHRof1.18(95%CI = 1.04-1.34), respectively.Dose-response metaregression showed a U-shaped relation of IGF-I and all-cause mortality (P = 0.003). The predicted HR for the increase in mortality comparing the 10th IGF-I with the 50th percentile was 1.56 (95% CI = 1.31-1.86); the predicted HR comparing the 90th with the 50th percentile was 1.29 (95% CI = 1.06-1.58). A U-shaped relationship was present for both cancer mortality and cardiovascular mortality. Conclusions: Both low and high IGF-I concentrations are associated with increased mortality in the general population. Copyright © 2011 by The Endocrine Society.
Authors & Co-Authors
Burgers, Anne Marij Geertruida
Netherlands, Leiden
Leids Universitair Medisch Centrum
Biermasz, Nienke Ruurdje
Netherlands, Leiden
Leids Universitair Medisch Centrum
Pereira, Alberto Martin
Netherlands, Leiden
Leids Universitair Medisch Centrum
Renehan, Andrew G.
United Kingdom, Manchester
Health Innovation Manchester
Zwahlen, Marcel
Switzerland, Bern
University of Bern
Egger, Matthias
Switzerland, Bern
University of Bern
United Kingdom, Bristol
University of Bristol
Dekkers, Olaf Matthijs
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 124
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1210/jc.2011-1377
ISSN:
19457197
Research Areas
Cancer
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Systematic review