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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the european group for blood and marrow transplantation
Acta Haematologica, Volume 124, No. 1, Year 2010
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Description
Background: Aplastic anemia (AA) is rarely described after a diagnosis of autoimmune disease (aID). Aims: To assess the prevalence of prior aID in patients with AA recorded in the registry of the European Group for Blood and Marrow Transplantation (EBMT) and to evaluate treatment and outcome. Methods: 1,251 AA patients from 18 EBMT centers were assessed. Results: Fifty patients (4%) were eligible: 22 males and 28 females with a median age of 46 years at the diagnosis of aID and of 51 years at the diagnosis of AA. Information on the treatment of AA was available in 49 patients: 38 received only immunosuppressive therapy (IST), 8 patients underwent hematopoietic stem cell transplantation (HSCT) - 6 as first-line therapy and 2 after failure of IST - whilst 3 patients had a spontaneous recovery. After a median follow-up of 3.19 years, 32 patients were alive, including 7 of the 8 patients who underwent HSCT. Only 6 of 32 patients who were alive at the last follow-up were receiving IST for AA. Conclusions: Most cases of AA following aID benefitted from IST or HSCT if a matched donor was available. Further prospective investigation is needed to assess the effects of IST on the outcome of underlying aID. Copyright © 2010 S. Karger AG, Basel.
Authors & Co-Authors
Cesaro, Simone
Italy, Padua
Università Degli Studi Di Padova
Italy, Verona
Azienda Ospedaliera Universitaria Integrata Verona
Marsh, Judith C.W.
United Kingdom, London
King's College Hospital
Tridello, Gloria
Italy, Padua
Università Degli Studi Di Padova
Rovò, Alicia
Switzerland, Basel
Universitätsspital Basel
Maury, Sébastien
France, Creteil
Hôpital Henri Mondor
Montante, Barbara
Italy, Rome
Azienda Ospedaliera San Camillo Forlanini
Masszi, Tamás
Hungary, Budapest
Szent Laszlo Hospital
van Lint, Maria Teresa
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Afanasyev, Boris V.
Russian Federation, Saint Petersburg
Pavlov University
Iriondo Atienza, Arturo
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Bierings, Marc B.
Netherlands, Utrecht
Wilhelmina Kinderziekenhuis
Carbone, Cecilia
Unknown Affiliation
Doubek, Michael
Czech Republic, Brno
Masaryk University
Lanino, Edoardo
Italy, Genoa
Istituto Giannina Gaslini
Sarhan, Mahmoud M.
Jordan, Amman
King Hussein Cancer Centre
Risitano, Antonio Maria
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Steinerova, Katerina
Czech Republic, Pilsen
Fakultní Nemocnice Plzeň
Wahlin, Anders C.E.
Sweden, Umea
Norrlands Universitetssjukhus
Pegoraro, Anna
Italy, Padua
Università Degli Studi Di Padova
Passweg, Jakob Robert
Switzerland, Geneva
University Hospital
Statistics
Citations: 20
Authors: 20
Affiliations: 18
Identifiers
Doi:
10.1159/000313783
ISSN:
00015792
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female