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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva
European Journal of Cancer, Volume 49, No. 16, Year 2013
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Description
Background Human papillomavirus (HPV) contribution in vulvar intraepithelial lesions (VIN) and invasive vulvar cancer (IVC) is not clearly established. This study provides novel data on HPV markers in a large series of VIN and IVC lesions. Methods Histologically confirmed VIN and IVC from 39 countries were assembled at the Catalan Institute of Oncology (ICO). HPV-DNA detection was done by polymerase chain reaction using SPF-10 broad-spectrum primers and genotyping by reverse hybridisation line probe assay (LiPA 25) (version 1). IVC cases were tested for p16INK4a by immunohistochemistry (CINtec histology kit, ROCHE). An IVC was considered HPV driven if both HPV-DNA and p16INK4a overexpression were observed simultaneously. Data analyses included algorithms allocating multiple infections to calculate type-specific contribution and logistic regression models to estimate adjusted prevalence (AP) and its 95% confidence intervals (CI). Results Of 2296 cases, 587 were VIN and 1709 IVC. HPV-DNA was detected in 86.7% and 28.6% of the cases respectively. Amongst IVC cases, 25.1% were both HPV-DNA and p16INK4a positive. IVC cases were largely keratinising squamous cell carcinoma (KSCC) (N = 1234). Overall prevalence of HPV related IVC cases was highest in younger women for any histological subtype. SCC with warty or basaloid features (SCC-WB) (N = 326) were more likely to be HPV and p16 INK4a positive (AP = 69.5%, CI = 63.6-74.8) versus KSCC (AP = 11.5%, CI = 9.7-13.5). HPV 16 was the commonest type (72.5%) followed by HPV 33 (6.5%) and HPV 18 (4.6%). Enrichment from VIN to IVC was significantly high for HPV 45 (8.5-fold). Conclusion Combined data from HPV-DNA and p16INK4a testing are likely to represent a closer estimate of the real fraction of IVC induced by HPV. Our results indicate that HPV contribution in invasive vulvar cancer has probably been overestimated. HPV 16 remains the major player worldwide. © 2013 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
de Sanjosé, Sílvia
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Alemany, Laia
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Ordi, J.
Spain, Barcelona
Universitat de Barcelona
Tous, Sara
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Alejo, María
Spain, Hospitalet de Llobregat
Hospital General D'hospitalet
Bigby, Susan M.
New Zealand, Auckland
Middlemore Hospital, Auckland
Joura, Elmar Armin
Austria, Vienna
Medizinische Universität Wien
Maldonado, Paula
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Laco, Jan
Czech Republic, Hradec Kralove
Fakultní Nemocnice Hradec Králové
Bravo, Ignacio G.
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Vidal-Bel, August
Spain, Barcelona
Hospital Universitari de Bellvitge
Guimerà, Núria
Netherlands, Rijswijk
Ddl Diagnostic Laboratory
Cross, Paul A.
United Kingdom, Tyne and Wear
Queen Elizabeth Hospital, Gateshead
Wain, Gerard Vincent
Australia, Sydney
Westmead Hospital
Petry, Karl Ulrich
Germany, Wolfsburg
Klinikum Wolfsburg
Mariani, Luciano
Italy, Rome
Irccs Regina Elena National Cancer Institute
Bergeron, Christine O.M.A.
France, Saint Ouen L'aumone
Laboratoire Pasteur Cerba
Mandys, Václav
Czech Republic, Prague
Charles University
Sica, Adela Rosa
Uruguay, Montevideo
Laboratorio de Anatomía Patológica Del Hospital de la Mujer
Felix, Ana
Portugal, Lisbon
Instituto Portugues de Oncologia de Francisco Gentil Lisboa
Usubütün, Alp
Turkey, Ankara
Hacettepe Üniversitesi
Seoud, Muhieddine
Lebanon, Beirut
American University of Beirut Medical Center
Hernández-Suárez, Gustavo
Colombia, Bogota
Instituto Nacional de Cancerología
Nowakowski, Andrzej Marcin
Poland, Lublin
Medical University of Lublin
Wilson, Godfrey E.
United Kingdom, Manchester
Manchester Royal Infirmary
Dalstein, Véronique
France, Reims
Chu de Reims
Hampl, Monika
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Kasamatsu, Elena Sachiko
Paraguay, San Lorenzo
Universidad Nacional de Asuncion
Lombardi, Luis Estuardo
Guatemala, America
Hospital General San Juan de Dios
Tinoco, Leopoldo
Ecuador, Quito
Hospital Oncológico Solca Núcleo de Quito
Alvarado Cabrero, Isabel J.
Mexico, Mexico
Instituto Mexicano Del Seguro Social
Perrotta, Myriam B.
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Bhatla, Neerja
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Agorastos, Theodoros
Greece, Thessaloniki
Aristotle University of Thessaloniki
Lynch, Charles F.
United States, Iowa City
University of Iowa
Goodman, Marc T.
United States, Honolulu
University of Hawaiʻi Cancer Center
Shin, Hairim
South Korea, Goyang
National Cancer Center, Gyeonggi
Vergeǐchik, G. I.
Belarus, Gomel
Gomel State Medical University
Jach, Robert
Poland, Krakow
Jagiellonian University Medical College
Cruz, M. O.L.Eugenia
Portugal, Coimbra
Centro Regional de Oncologia Coimbra
Velasco-Alonso, Julio
Spain, Asturias
Hospital San Agustin
Molina, Carla
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Bornstein, Jacob
Israel, Ramat Gan
Bar-ilan University
Ferrera, Annabelle
Honduras, Tegucigalpa
Universidad Nacional Autónoma de Honduras
Domingo, Efrén Javier Javier
Philippines, Manila
University of the Philippines Manila
Chou, Cheng-Yang
Taiwan, Tainan
National Cheng Kung University College of Medicine
Banjo, Adekunbiola Aina Fehintola
Nigeria, Lagos
Lagos University Teaching Hospital
Castellsagué, X.
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Pawlita, Michael
Germany, Heidelberg
German Cancer Research Center
Lloveras, Belén
Spain, Barcelona
Hospital Del Mar
Quint, Wim G.V.
Netherlands, Rijswijk
Ddl Diagnostic Laboratory
Muñoz, Nubia
Colombia, Cali
Universidad Del Valle, Cali
Bosch, Francisco Xavier
Spain, Hospitalet de Llobregat
Institute Catala Oncologia
Statistics
Citations: 321
Authors: 53
Affiliations: 48
Identifiers
Doi:
10.1016/j.ejca.2013.06.033
ISSN:
09598049
e-ISSN:
18790852
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Participants Gender
Female