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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Increase of malaria attacks among children presenting concomitant infection by Schistosoma mansoni in Senegal
Malaria Journal, Volume 3, Article 43, Year 2004
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Description
Helminthic infections concomitant with malaria are common in inter-tropical areas. A recent study showed that mice co-infected with Schistosoma mansoni and Plasmodium chabaudi develop higher P. chabaudi parasitaemia and had a higher mortality rate. This important observation deserved to be further investigated among human populations. Malaria attacks were recorded in 512 children aged 6-15 years living in Richard Toll (Northern Senegal) among whom 336 were infected by S. mansoni, and 175 were not. The incidence rate of malaria attacks was significantly higher among S. mansoni-infected individuals, particularly those carrying the highest worm loads, as compared to uninfected subjects (26.6% versus 16,4 %). In contrast, the rate of malaria attacks was lower, without reaching significance, in medium grade S. mansoni infections. Thus, infection by S. mansoni affects susceptibility to malaria, but this can vary according to the intensity of parasite load. The immunological mechanisms underlying this dual effect need to be further explored. © 2004 Sokhna et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Sokhna, Cheikh Sadibou
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Le-Hesran, Jean Yves
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Mbaye, Pape A.
Senegal
Prog. de Lutte Contre la Bilharziose
Akiana, Jean
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Camara, Pape
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Diop, Mamadou B.
Unknown Affiliation
Ly, Abdoulaye
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Druilhe, Pierre L.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 176
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1186/1475-2875-3-43
ISSN:
14752875
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Senegal