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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage
Food and Chemical Toxicology, Volume 48, No. 3, Year 2010
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Description
Liver disorders are one of the common recent problems affects on the human health. These disorders due to many environmental polluted sources. Many herbal, medicinal and pharmaceutical plants and their extracts are widely studied by many researchers. Silybum marianum got a bright reputation in relieve the liver diseases, and that might be for the potent silymarin mixture. Mechanism of action for silymarin conducted mainly to the antiradical and anticarcinogenic roles. Ethyl acetate (100 mg/kg bw) and ethanol seed extracts for S. marianum (100 mg/kg bw) were tested against the injection (i.p.) by carbon tetrachloride (2 ml/kg bw) the inducer of liver damage. Their activity were compared with standard hepatic drug hepaticum (100 mg/kg bw) for 10 days. Ethanolic extract showed the most significantly decrease in the liver enzymes. For the oxidative experiments, ethyl acetate showed the most increase for glutathione level and the risk factor HDL/LDL significantly. Hepaticum was the most powerful group for the significant decreasing for malondialdehyde and fucosidase activity. Some equal improvements were noticed in the histopathological studies for the protective groups. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Shaker, Emad S.
Egypt, Minya
Minia University
Mahmoud, H.
Egypt, Minya
Minia University
Mnaa, Said
Egypt, Shibin el Kom
Menoufia University
Statistics
Citations: 315
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.fct.2009.12.011
ISSN:
02786915
Research Areas
Environmental