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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions
Antiviral Research, Volume 78, No. 1, Year 2008
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Description
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks. In recent years, laboratory research on the filoviruses has produced treatments and vaccines that are effective in laboratory animals and that could potentially drastically reduce case-fatality rates and curtail outbreaks in humans. However, there are significant challenges in clinical testing of these products and eventual delivery to populations in need. Most cases of filovirus infection are recognized only in the setting of large outbreaks, often in the most remote and resource-poor areas of sub-Saharan Africa, with little infrastructure and few personnel experienced in clinical research. Significant political, legal, and socio-cultural barriers also exist. Here, we review the present research priorities and environment for field study of the filovirus hemorrhagic fevers and outline a strategy for future prospective clinical research on treatment and vaccine prevention. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Bausch, Daniel G.
United States, New Orleans
Tulane University Health Sciences Center
Sprecher, Armand G.
Belgium, Brussels
Medecins Sans Frontieres, Brussels
Jeffs, Benjamin
Switzerland, Geneva
Medecins Sans Frontieres
Boumandouki, P.
Congo
Ministry of Health and Population
Statistics
Citations: 82
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.antiviral.2008.01.152
ISSN:
01663542
Research Areas
Infectious Diseases
Study Design
Cohort Study