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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C
Journal of Hepatology, Volume 56, No. 3, Year 2012
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Description
Background & Aims: Polymorphisms in the region of the interleukin (IL)28B gene have been associated with pegylated-interferon (PEG-IFN) and ribavirin treatment response mainly in genotype 1 HCV infections. However, there are few data on HCV genotype 4 (HCV-4) infection. We evaluated, in a unique well-characterized cohort of HCV-4 patients, the association of IL28B polymorphism with response to treatment or liver disease severity. Methods: This study included 164 HCV-4 patients from different ethnic groups (Egyptian, European, and Sub-Saharan African). Among these patients, 82 were studied for response and 160 for disease severity. Free DNA extracted from all the 164 patient's serum samples was analyzed by direct sequencing of the SNP rs12979860 of IL28B. Genetic and bio-clinical features from patients having sustained virological response (43 SVR patients) and from those who did not respond to treatment or had a relapse after the end of the treatment (39 NR patients) were compared. IL28B polymorphism was compared between the 78 patients with mild fibrosis (Metavir score F0-F1) and the 82 with advanced fibrosis (F2-F4). Results: Our data showed a better treatment response rate of the C allele of the IL28B gene SNP rs12979860 (p = 0.0008). The response rates were 81.8%, 46.5%, and 29.4% for genotype CC, CT, and TT, respectively. No significant relationship was found between rs12979860 and the severity of the disease. Conclusions: The SNP rs12979860 is strongly associated with SVR in patients infected with HCV-4, but not with liver disease severity. Analysis of IL28B genotype might be used to guide treatment for these patients. © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Asselah, Tarik
France, Paris
Université Paris Cité
De Muynck, Simon
France, Paris
Université Paris Cité
Bröet, Philippe
France, Gif-sur-yvette
Université Paris-saclay
Masliah-Planchon, Julien
France, Clichy
Hôpital Beaujon
France, Paris
Inserm
Blanluet, Maud
France, Clichy
Hôpital Beaujon
France, Paris
Inserm
Biche, Ivan
France, Clichy
Hôpital Beaujon
France, Paris
Inserm
Lapalus, Martine
France, Paris
Université Paris Cité
Martinot-Peignoux, Michelle
France, Paris
Université Paris Cité
Lada, Olivier
France, Paris
Université Paris Cité
Estrabaud, Emilie
France, Paris
Université Paris Cité
Zhang, Qian
France, Paris
Université Paris Cité
El-Ray, Ahmed Ali
Egypt, Giza
Clinical Medical Division
Vidaud, Dominique
France, Clichy
Hôpital Beaujon
France, Paris
Inserm
Ripault, Marie Pierre
France, Paris
Université Paris Cité
Boyer, Nathalie
France, Paris
Université Paris Cité
Bédossa, Pierre
France, Clichy
Hôpital Beaujon
Valla, Dominique Charles
France, Paris
Université Paris Cité
Vidaud, Michel
France, Clichy
Hôpital Beaujon
France, Paris
Inserm
Marcellin, Patrick M.
France, Paris
Université Paris Cité
Statistics
Citations: 189
Authors: 19
Affiliations: 5
Identifiers
Doi:
10.1016/j.jhep.2011.09.008
ISSN:
01688278
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cohort Study