Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Dendritic cell anergy results from endotoxemia in severe malnutrition
Journal of Immunology, Volume 183, No. 4, Year 2009
Notification
URL copied to clipboard!
Description
Malnutrition predicts an increased risk of morbidity and mortality from infection. Defects in cell-mediated immunity, such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in vitro, are well characterized. There has been no convincing mechanism proposed for these T cell defects. However, as T cell responses rely on signals received from APCs, this study evaluates dendritic cell (DC) function in children with severe malnutrition. Repeated sampling of peripheral blood from 81 severely malnourished children at the University Teaching Hospital, Lusaka, Zambia, demonstrated for the first time a defect in DC numbers in children with malnutrition (28 per microliter) and a recovery in cell number (48 per microliter; p < 0.01) with standard treatment. We describe normal DC maturation in the majority of malnourished children. However, in 17% of our study patients, in association with endotoxemia we describe the novel finding of DC maturation failure (downregulation rather than up-regulation of HLA-DR). There was a strong correlation between the strength of HLA-DR up or down-regulation and the generation of IL-10 (r = -0.481; p = 0.003). These "anergic" DCs failed to support T cell proliferation. Defects in DC number and the immunosuppressive phenotype of DCs from severely malnourished children with endotoxemia provide a rational basis for the anergy found in severe malnutrition. Copyright © 2009 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Hughes, Stephen Miles
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Zambia, Lusaka
University Teaching Hospital Lusaka
Amadi, Beatrice C.
Zambia, Lusaka
University Teaching Hospital Lusaka
Mwiya, Mwiya
Zambia, Lusaka
University Teaching Hospital Lusaka
Nkamba, Hope C.
Zambia, Lusaka
University Teaching Hospital Lusaka
Tomkins, Andrew Marvin
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Goldblatt, David L.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Statistics
Citations: 72
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.4049/jimmunol.0803518
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Food Security
Health System And Policy
Maternal And Child Health
Study Locations
Zambia