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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Latent tuberculosis in children and youth with type 1 diabetes mellitus in Dar es Salaam, Tanzania: a cross section survey
BMC Infectious Diseases, Volume 23, No. 1, Article 740, Year 2023
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Description
Background: Data for latent tuberculosis in patients with type 1 Diabetes in Africa is limited. We assessed the prevalence of latent tuberculosis in youth and children with type 1 Diabetes in Dar es Salaam –Tanzania. Methods: Our cross-sectional study recruited children and youth with T1DM by stage of puberty, glycaemic control, and age at diagnosis from January to December 2021 in Dar es Salaam. Participants were screened for the presence of latent Tuberculosis using the QuantiFERON test. A positive test was considered to have latent TB. Results: Of the 281 participants, the mean age was 19 (± 6) years, 51.2% were female, and 80.8% had either a primary or secondary level of education at baseline. The prevalence of latent TB was 14.9% and was slightly higher in females (52.4%) than in males. This difference, however, was insignificant (p > 0.05). On the other hand, the proportion of latent TB was significantly higher in uncontrolled HbA1c levels (76.2%) than in those with controlled HbA1c (23.8%) [p = 0.046]. Duration of diabetes and age at diagnosis did not affect the occurrence of latent Tuberculosis [p > 0.05]. Meanwhile, in the regression model, participants with latent TB were more likely to have uncontrolled HbA1c. [p = 0.045] Conclusions: Despite the methodological limitations, this survey highlights the high prevalence of latent TB among children and youth with diabetes; shouting for better control. These results clearly show the need to screen for Tuberculosis in children and youth with diabetes and start them on prevention as per protocol, especially in tuberculosis-endemic areas like Tanzania. © 2023, The Author(s).
Authors & Co-Authors
Majaliwa, Edna Siima
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Tanzania, Dar es Salaam
Muhimbili National Hospital
Muze, Kandi Catherine
Tanzania, Dar es Salaam
Muhimbili National Hospital
Godfrey, Evance K.
Tanzania, Dar es Salaam
Muhimbili National Hospital
Byashalira, Kenneth Cleophace
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Tanzania, Siha
Kibong’oto Infectious Diseases Hospital
Mmbaga, Blandina Theophil
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Tanzania, Moshi
Kilimanjaro Clinical Research Institute
Ramaiya, Kaushik Laxmidas
Tanzania, Dar es Salaam
Shree Hindu Mandal Hospital
Mfinanga, Sayoki Godfrey Mrinde
Tanzania, Tanga
National Institute for Medical Research Tanga
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Tanzania, Dar es Salaam
Alliance for Africa Health and Research A4a
Statistics
Citations: 1
Authors: 7
Affiliations: 8
Identifiers
Doi:
10.1186/s12879-023-08753-4
ISSN:
14712334
Research Areas
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Tanzania
Participants Gender
Female