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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic study of ICAM1 in clinical malaria in Senegal
Tissue Antigens, Volume 65, No. 5, Year 2005
Notification
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Description
Many genes have been implicated in the risk of severe malaria, generally based on candidate gene studies in case/control populations. Among these genes, there has been conflicting reports for the implication of a variant of the intercellular adhesion molecule 1 (ICAM1), ICAM1Kilifi, in the risk of severe malaria, while in vitro studies provided independent support for a functional role of this variant. In order to explore the possible implication of ICAM1 in the susceptibility/resistance to malaria and to try to understand its clinical relevance in the disease process, we have conducted linkage and association studies of ICAM1 in two Senegalese villages located in regions of endemic malaria. We explored the full genetic variability of ICAM1, and tested it on several clinical malarial traits which are under genetic control, focusing principally on variables related to the parasite density and the number of malarial attacks. Our study provides no evidence for a role of ICAM1 variability on the malarial phenotypes studied. Copyright © Blackwell Munksgaard 2005.
Authors & Co-Authors
Ndiaye Diallo, Rokhaya
France, Paris
Institut Pasteur, Paris
Sakuntabhai, Anavaj
France, Paris
Institut Pasteur, Paris
Casadémont, Isabelle
France, Paris
Institut Pasteur, Paris
Rogier, Christophe
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Tall, Adama
Senegal, Dakar
Institut Pasteur de Dakar
Trape, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Spiegel, André
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Senegal, Dakar
Institut Pasteur de Dakar
Diéye, Alioune M.
Senegal, Dakar
Institut Pasteur de Dakar
Julier, Cécile
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 19
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1111/j.1399-0039.2005.00388.x
ISSN:
00012815
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Senegal