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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A new long-acting liposomal topical antifungal formula: Human clinical study
Cornea, Volume 31, No. 2, Year 2012
Notification
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Description
PURPOSE: To study the clinical effect of a topical controlled-release ophthalmic fluconazole liposomal formulation on patients with Candida keratitis. METHODS: Eleven eyes of 11 patients with Candida albicans corneal fungal infection (proved by cultures) were included in this study. All were treated with topical liposomal fluconazole (2 mg/mL) 3 times daily. The response to the treatment was divided into 3 categories: complete improvement, complete healing with scar formation at the end of 1 month; partial improvement, decrease in the ulcer size at the end of 1 month; and no improvement, includes extension of ulcer size and/or perforation that necessitates other approaches of management. The patients were examined daily over a 30-day period, and the results were recorded. RESULTS: Eleven eyes with C. albicans as proved with laboratory cultures were included in this study (7 men and 4 women). Three of the patients included in this study had diabetes mellitus, and 2 patients had rheumatoid arthritis. Mean corneal ulcer diameter (mean of both horizontal and vertical diameters) was 5.5 mm (range, 3.5-6.5 mm). Mean duration of the ulcers at presentation was 7.6 days (range, 3-14 days). Eight patients improved after 1 month, whereas 1 patient had partial improvement and 2 patients did not improve and underwent amniotic membrane transplantation. One of the nonimproved patients progressed to perforation, and keratoplasty was performed. Mean decimal notation best-corrected visual acuity on presentation was 0.06, which was not improved at the end of the study. CONCLUSIONS: Therapy with topical liposomal fluconazole (2 mg/mL) carries a high success rate and fast effect in treating patients with C. albicans keratitis. Copyright © 2012 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Abdel-Rhaman, Mohamed S.
Egypt, Ismalia
Faculty of Medicine
Soliman, Wael M.
Egypt, Ismalia
Faculty of Medicine
Habib, Fawzia Sayed
Egypt, Asyut
Faculty of Pharmacy
Fathalla, Dina
Egypt, Asyut
Faculty of Pharmacy
Statistics
Citations: 14
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1097/ICO.0b013e318221cf12
e-ISSN:
15364798
Research Areas
Health System And Policy
Noncommunicable Diseases
Participants Gender
Male
Female