Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prophylaxis of Aphakic Cystoid Macular Edema without Corticosteroids: A Paired-comparison, Placebo-controlled Double-masked Study
Ophthalmology, Volume 97, No. 10, Year 1990
Notification
URL copied to clipboard!
Description
Prior investigations have reported that topical nonsteroidal anti-inflammatory drug (NSAID) therapy prevents the development of postoperative angiographic signs of angiographic cystoid macular edema (CME). However, these studies include concurrent use of corticosteroids. The current study reports therapeutic efficacy for ketorolac ophthalmic solution (an NSAID) in the prophylaxis of angiographic aphakic CME (ACME) after cataract surgery without concurrent corticosteroids for the first time. Fifty patients with bilateral cataracts were enrolled in this placebo-controlled, paired-comparison, double-masked study. Eleven patients had evidence of angiographic ACME on postoperative day 40. Two of these patients demonstrated bilateral ACME, one patient had ACME in the NSAID-treated eye, and eight patients demonstrated ACME in the placebo-treated eye. This is a statistically significant difference favoring drug treatment. The signs of anterior ocular inflammation were greater in the eyes with ACME. This study suggests prophylactic treatment of ACME may be possible without the risks of concurrent corticosteroid toxicity. In addition, a higher incidence of ACME in black patients (22%) is observed in this study than has been recognized previously. © 1990, American Academy of Ophthalmology, Inc. All rights reserved.
Authors & Co-Authors
Flach, Allan J.
United States, Emeryville
University of California
United States, Iowa City
Veterans Administration
Stegman, Robert C.
South Africa, Pretoria
Ga-rankuwa Hospital
Graham, John
South Africa, Pretoria
Ga-rankuwa Hospital
Kruger, Louie P.
South Africa, Pretoria
Ga-rankuwa Hospital
Statistics
Citations: 112
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/S0161-6420(90)32423-5
Research Areas
Health System And Policy
Study Design
Cohort Study