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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A cohort study of post-COVID-19 condition across the Beta, Delta, and Omicron waves in South Africa: 6-month follow-up of hospitalized and nonhospitalized participants
International Journal of Infectious Diseases, Volume 128, Year 2023
Notification
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Description
Objectives: The study aimed to describe the prevalence of and risk factors for post-COVID-19 condition (PCC). Methods: This was a prospective, longitudinal observational cohort study. Hospitalized and nonhospitalized adults were randomly selected to undergo telephone assessment at 1, 3, and 6 months. Participants were assessed using a standardized questionnaire for the evaluation of symptoms and health-related quality of life. We used negative binomial regression models to determine factors associated with the presence of ≥1 symptoms at 6 months. Results: A total of 46.7% of hospitalized and 18.5% of nonhospitalized participants experienced ≥1 symptoms at 6 months (P ≤0.001). Among hospitalized people living with HIV, 40.4% had persistent symptoms compared with 47.1% among participants without HIV (P = 0.108). The risk factors for PCC included older age, female sex, non-Black race, presence of a comorbidity, greater number of acute COVID-19 symptoms, hospitalization/COVID-19 severity, and wave period (lower risk of persistent symptoms for the Omicron compared with the Beta wave). There were no associations between self-reported vaccination status with persistent symptoms. Conclusion: The study revealed a high prevalence of persistent symptoms among South African participants at 6 months but decreased risk for PCC among participants infected during the Omicron BA.1 wave. These findings have serious implications for countries with resource-constrained health care systems. © 2022 The Author(s)
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9800016/bin/mmc1.docx
Authors & Co-Authors
Jassat, Waasila
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
Right to Care
Mudara, Caroline
South Africa, Johannesburg
National Health Laboratory Service
Vika, Caroline
South Africa, Johannesburg
National Health Laboratory Service
Welch, Richard K.
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
Right to Care
Arendse, Tracy
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
Right to Care
Dryden, Murray
South Africa, Johannesburg
National Health Laboratory Service
Blumberg, Lucille Hellen
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
Right to Care
Mayet, Natalie T.
South Africa, Johannesburg
National Health Laboratory Service
Tempia, Stefano
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Parker, Arifa
South Africa, Stellenbosch
Stellenbosch University
Nel, Jeremy Stephen
South Africa, Johannesburg
University of the Witwatersrand
Perumal, Rubeshan
South Africa, Durban
University of Kwazulu-natal
South Africa, Tygerberg
South African Medical Research Council
Groome, Michelle J.
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Conradie, Francesca M.
South Africa, Johannesburg
University of the Witwatersrand
Ndjeka, Norbert O.
South Africa, Durban
University of Kwazulu-natal
Sigfrid, Louise A.
United Kingdom, Oxford
University of Oxford
Merson, Laura
United Kingdom, Oxford
University of Oxford
Cohen, Cheryl D.
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Statistics
Citations: 14
Authors: 18
Affiliations: 8
Identifiers
Doi:
10.1016/j.ijid.2022.12.036
ISSN:
12019712
Research Areas
Covid
Disability
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
South Africa
Participants Gender
Female