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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reproducibility of a histogenetic classification of thymic epithelial tumours
Histopathology, Volume 26, No. 4, Year 1995
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Description
A histogenetic classification of thymic epithelial neoplasms proposed by Müller‐Hermelink and co‐workers has been shown by a number of recent studies to be of clinical and prognostic value. Reproducibility is an important criterion for the acceptance of any new classification for general diagnostic use. The reproducibility of this classification was tested on 51 cases of thymic epithelial neoplasia, by comparing results obtained by pathologists working from published criteria only with those results obtained by the pathologists who developed the classification. In 78% of cases there was complete concordance of results. Analysis of the 22% discordant cases showed that this discordance was due to a degree of subjectivity in determining cut‐off points between categories adjacent to each other in the morphological spectrum of thymic epithelial neoplasia (medullary v. mixed, cortical v. well‐differentiated thymic carcinoma). In terms of the important clinical distinction between benign (medullary and mixed) thymomas and those with more aggressive biological behaviour (cortical types and well‐differentiated thymic carcinoma), the degree of reproducibility was 96%. The high degree of reproducibility of this histogenetic classification of thymic epithelial neoplasms should facilitate its acceptance and use in routine diagnostic pathology. Copyright © 1995, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Close, Pauline M.
South Africa, Observatory
Groote Schuur Hospital
KIRCHNER, T.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uys, Cornelius J.
South Africa, Observatory
Groote Schuur Hospital
Müller-Hermelink, Hans Konrad
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 45
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2559.1995.tb00195.x
ISSN:
03090167
e-ISSN:
13652559
Research Areas
Cancer