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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
NT-proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa: Research paper
British Journal of Haematology, Volume 150, No. 1, Year 2010
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Description
N-terminal (NT) pro-brain natriuretic peptide (proBNP) ≥160 ng/l has a 78% positive predictive value for pulmonary hypertension and is associated with increased mortality in US sickle cell disease patients, but the importance in sickle cell disease patients in Africa is not known. In a cross-sectional study at Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria, we studied 133 hydroxycarbamide-naïve Nigerian sickle cell anaemia patients aged 18-52 years at steady-state and 65 healthy controls. Twenty-six percent of patients versus 5% of controls had NT-proBNP ≥160 ng/l (P = 0·0006). By logistic regression among the patients, human immunodeficiency virus seropositivity, higher serum ferritin and lower haemoglobin or higher lactate dehydrogenase independently predicted elevated NT-proBNP. After adjustment for haemoglobin concentration, elevated NT-proBNP concentration was associated with an estimated 7·8-fold increase in the odds of severe functional impairment, defined as an inability to walk more than 300 m in 6 min (95% confidence interval 1·5-32·6; P = 0·005). Similarly, elevated tricuspid regurgitation velocity was associated with an estimated 5·6-fold increase in the odds of functional impairment (95% confidence interval 1·5-21·0; P = 0·011). In conclusion, NT-proBNP elevation is common and is associated with markers of anaemia, inflammation and iron status and with severe functional impairment among sickle cell anaemia patients in Nigeria. © 2010 Blackwell Publishing Ltd.
Authors & Co-Authors
Aliyu, Zakari Yusufu
Nigeria
Taraba State Specialist Hospital
United States, Washington, D.c.
The Center for Sickle Cell Disease
Suleiman, Aisha Mera
Nigeria, Zaria
Ahmadu Bello University
Attah, Ester
Nigeria, Zaria
Ahmadu Bello University
Mamman, Aisha Indo
Nigeria, Zaria
Ahmadu Bello University
Babadoko, Ahmadu Aliyu
Nigeria, Zaria
Ahmadu Bello University
Nouraie, Mehdi
United States, Washington, D.c.
The Center for Sickle Cell Disease
Mendelsohn, Laurel
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Kato, Gregory J.
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Gordeuk, Victor R.
United States, Washington, D.c.
The Center for Sickle Cell Disease
Gladwin, Mark T.
United States, Pittsburgh
University of Pittsburgh
Statistics
Citations: 15
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-2141.2010.08195.x
ISSN:
00071048
e-ISSN:
13652141
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Nigeria