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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Randomized trial of chlorambucil for primary biliary cirrhosis
Gastroenterology, Volume 91, No. 6, Year 1986
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Description
Twenty-four patients with primary biliary cirrhosis were entered into a prospective, randomized trial of chlorambucil therapy. Thirteen patients received chlorambucil (0.5-4 mg/day) and 11 patients received no therapy; all have been followed for 2-6 yr (mean, 4.1 yr). Two control but no treated patients died. Average serum bilirubin, serum aspartate aminotransferase activities, and albumin levels improved or remained unchanged in treated patients but worsened in controls. Serum alkaline phosphatase levels did not change in either group. Immunoglobulin M levels decreased and became normal in all treated patients but in only 3 control patients. Liver biopsy histology revealed an improvement in inflammatory cell infiltrate in treated patients in comparison with controls, but no significant change in degree of fibrosis or the histologic stage of disease. Side effects of therapy included bone marrow suppression necessitating discontinuation of the drug in 4 patients. These findings indicate that chlorambucil therapy may retard the progression of primary biliary cirrhosis. Whether such therapy will ultimately decrease morbidity and improve survival in this disease can only be demonstrated by large-scale, placebo-controlled trials. © 1986.
Authors & Co-Authors
Peters, Marion G.
United States, Bethesda
National Institutes of Health Nih
United Kingdom, Glasgow
Western Infirmary
Minuk, Gerald Yosel
United States, Bethesda
National Institutes of Health Nih
United Kingdom, Glasgow
Western Infirmary
Dusheiko, Geoffrey M.
United States, Bethesda
National Institutes of Health Nih
United Kingdom, Glasgow
Western Infirmary
Campbell, Gregory A.
United States, Bethesda
National Institutes of Health Nih
United Kingdom, Glasgow
Western Infirmary
MacSween, Roderick Norman Mciver
United States, Bethesda
National Institutes of Health Nih
United Kingdom, Glasgow
Western Infirmary
Statistics
Citations: 152
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/0016-5085(86)90183-6
ISSN:
00165085
Study Design
Cohort Study