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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli: Results of the CANWARD 2007-2009 study
Diagnostic Microbiology and Infectious Disease, Volume 69, No. 3, Year 2011
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Description
The national prevalence of extended-spectrum β-lactamase (ESBL)-producing (2007: 3.4%, 2008: 4.9%, 2009: 4.3%) and AmpC β-lactamase (AmpC)-producing (2007: 0.8%, 2008: 3.2%, 2009: 2.7%) Escherichia coli in Canadian hospitals have fluctuated from 2007 to 2009. Rates of co-resistance to non-lactam agents are elevated, and multidrug-resistant (MDR) phenotype were observed among E. coli strains producing ESBLs (83.3% MDR) and AmpCs (31.0%). The majority (>98%) of isolates remained susceptible to colistin, tigecycline, amikacin, and the carbapenems. CMY-2 encoding gene was detected in 52.9% of AmpC-producing strains, while blaCTX-M-15 (65.2%) was the predominant ESBL genotype. A total of 50.3% of ESBL-producing E. coli and 21.4% of AmpC producers belonged to the ST131 clone. In conclusion, ESBL- and AmpC-producing E. coli are established in Canadian hospitals; and although the prevalence rates of these isolates remain low, they are often MDR and associated with the ST131 clone. © 2011 Elsevier Inc.
Authors & Co-Authors
Zhanel, George G.
Canada, Winnipeg
University of Manitoba
Pitout, Johann D.D.
Canada, Calgary
University of Calgary
Mulvey, Michael Richard
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Lagacé-Wiens, Philippe R.
Canada, Winnipeg
University of Manitoba
Canada, Winnipeg
Hôpital St-boniface
Hoban, Daryl J.
Canada, Winnipeg
University of Manitoba
Canada, Winnipeg
Health Sciences Centre Winnipeg
Statistics
Citations: 58
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/j.diagmicrobio.2010.10.029
ISSN:
07328893
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study