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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats
Nutrition, Volume 27, No. 5, Year 2011
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Description
Objectives: The aims of the present study were to evaluate the antioxidant, radical scavenging, and metal-chelating activity of whey protein concentrate (WPC) and Spirulina alone or in combination in vitro and to evaluate their hepatoprotective effects against CCl4 in vivo. Methods: Five concentrations (20, 40, 60, 80, and 100 mg/100 mL) of WPC, Spirulina, and their combination were tested in vitro. In the in vivo study, eight groups of male rats comprised the control group and the groups treated with WPC, Spirulina alone, or in combination with or without CCl4 were used. Results: The in vitro study showed that WPC and Spirulina showed antioxidant, radical scavenging, and metal-chelating activities in dose-dependent manner. The in vivo study showed that both agents succeeded in preventing liver damage induced by CCl4. This prevention was more pronounced in rats receiving the combination of WPC and Spirulina. Conclusion: Whey protein concentrate and Spirulina have free radical scavenging properties and antioxidant activity. © 2011 Elsevier Inc.
Authors & Co-Authors
Gad, Ahmed Saad
Egypt, Giza
National Research Centre
Khadrawy, Yasser Ashry
Egypt, Giza
National Research Centre
El-Nekeety, Aziza Abdel Salam
Egypt, Giza
National Research Centre
Mohamed, Sherif R.
Egypt, Giza
National Research Centre
Hassan, Nabila Salah
Egypt, Giza
National Research Centre
Abdel-Wahhab, Mosaad Attia
Egypt, Giza
National Research Centre
Statistics
Citations: 211
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.nut.2010.04.002
ISSN:
08999007
Study Design
Randomised Control Trial
Participants Gender
Male