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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Bioactive diterpenes from the fruits of Detarium microcarpum
Journal of Natural Products, Volume 69, No. 5, Year 2006
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Description
A fruit pulp extract of Detarium microcarpum showed inhibition of the growth of the plant pathogenic fungus Cladosporium cucumerinum and of the enzyme acetylcholinesterase, implicated in Alzheimer's disease. Fractionation of this extract led to the isolation of four new clerodane diterpenes, 3,4-epoxyclerodan-13E-en-15-oic acid (1), 5α,8α(2-oxokolavenic acid) (2), 3,4-dihydroxyclerodan-13E-en-15-oic acid (4), and 3,4-dihydroxyclerodan- 13Z-en-15-oic acid (5). Also isolated were 2-oxokolavenic acid (3) and copalic acid (6). Structure elucidation of the compounds was carried out by spectroscopic data interpretation and by the X-ray crystallography of 2 and 4. Three of the new clerodane diterpenes (1, 2, and 5) showed both antifungal activity and inhibition of acetylcholinesterase, and 3 showed a slight inhibition of this enzyme. © 2006 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Cavin, Anne Laure
Switzerland, Geneva
Université de Genève
Hay, Anne Emmanuelle
Switzerland, Geneva
Université de Genève
Marston, Andrew
Switzerland, Geneva
Université de Genève
Stoeckli-Evans, Helen
Switzerland, Neuchatel
Université de Neuchâtel
Scopelliti, Rosario
Switzerland, Lausanne
Université de Lausanne Unil
Diallo, Drissa
Mali, Bamako
National Institute of Research in Public Health
Hostettmann, Kurt
Switzerland, Geneva
Université de Genève
Statistics
Citations: 52
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1021/np058123q
ISSN:
01633864