Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Emergence of trimethoprim resistance gene dfrG in Staphylococcus aureus causing human infection and colonization in sub-Saharan Africa and its import to Europe
Journal of Antimicrobial Chemotherapy, Volume 69, No. 9, Article dku174, Year 2014
Notification
URL copied to clipboard!
Description
Objectives: Co-trimoxazole (trimethoprim/sulfamethoxazole) is clinically valuable in treating skin and soft tissue infections (SSTIs) caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA). The genetic basis of emerging trimethoprim/sulfamethoxazole resistance in S. aureus from Africa is unknown. Such knowledge is essential to anticipate its further spread. We investigated the molecular epidemiology of trimethoprim resistance in S. aureus collected in and imported from Africa. Methods: Five hundred and ninety-eight human S. aureus isolates collected at five locations across sub-Saharan Africa [Gabon, Namibia, Nigeria (two) and Tanzania] and 47 isolates from travellers treated at six clinics in Europe because of SSTIs on return from Africa were tested for susceptibility to trimethoprim, sulfamethoxazole and trimethoprim/ sulfamethoxazole, screened for genes mediating trimethoprim resistance in staphylococci [dfrA (dfrS1), dfrB, dfrG and dfrK] and assigned to spa genotypes and clonal complexes. Results: In 313 clinical and 285 colonizing S. aureus from Africa, 54% of isolates were resistant to trimethoprim, 21% to sulfamethoxazole and 19% to trimethoprim/sulfamethoxazole. We found that 94% of trimethoprim resistance was mediated by the dfrG gene. Of the 47 S. aureus isolates from travellers with SSTIs, 27 (57%) were trimethoprim resistant and carried dfrG. Markers of trimethoprim resistance other than dfrG were rare. The presence of dfrG genes in S. aureus was neither geographically nor clonally restricted. Conclusions: dfrG, previously perceived to be an uncommon cause of trimethoprim resistance in human S. aureus, is widespread in Africa and abundant in imported S. aureus from ill returning travellers. These findings may foreshadow the loss of trimethoprim/sulfamethoxazole for the empirical treatment of SSTIs caused by community-associated MRSA. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Nurjadi, Dennis
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Olalekan, Adesola Olufunmilayo
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Nigeria, Ogbomoso
Ladoke Akintola University of Technology
Layer, Franziska
Germany, Berlin
Robert Koch Institute
Shittu, Adebayo Osagie
Nigeria, Ife
Obafemi Awolowo University
Alabi, Abraham Sunday
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Ghebremedhin, B.
Germany, Magdeburg
Medizinische Fakultät Und Uniklinikum Magdeburg
Germany, Witten
Universität Witten/herdecke
Germany, Wuppertal
Helios Klinikum Wuppertal
Schaumburg, Frieder
Germany, Munster
Universitätsklinikum Münster
Hofmann-Eifler, Jonas
Tanzania, Ifakara
Ifakara Health Institute
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
van Genderen, Perry J.J.
Netherlands, Rotterdam
Instituut Voor Tropische Ziekten
Caumes, Éric
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Sorbonne Université
Fleck, Ralf
Germany, Tubingen
Tropenklinik Paul-lechler-krankenhaus
Mockenhaupt, Frank Peter
Germany, Berlin
Charité – Universitätsmedizin Berlin
Herrmann, Mathias
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Kern, Winfried Vincenz
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Abdulla, Salim Mohammed K.
Tanzania, Ifakara
Ifakara Health Institute
Grobusch, Martín Peter
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Netherlands, Amsterdam
Universiteit Van Amsterdam
Kremsner, Peter G.
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Wolz, Christiane
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Zanger, Philipp
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Statistics
Citations: 86
Authors: 19
Affiliations: 18
Identifiers
Doi:
10.1093/jac/dku174
ISSN:
03057453
e-ISSN:
14602091
Research Areas
Cancer
Genetics And Genomics
Study Locations
Gabon
Namibia
Nigeria
Tanzania