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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma
Oncogene, Volume 25, No. 7, Year 2006
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Description
Hepatitis B virus (HBV)-encoded X antigen (HBxAg) contributes to the development of hepatocellular carcinoma (HCC). A frequent characteristic of HCC is reduced or absent expression of the cell adhesion protein, E-cadherin, although it is not known whether HBxAg plays a role. To address this, the levels of E-cadherin were determined in HBxAg-positive and -negative HepG2 cells in culture, and in tumor and surrounding nontumor liver from a panel of HBV carriers. The results showed an inverse relationship between HBxAg and E-cadherin expression both in tissue culture and in vivo. In HBxAg-positive cells, E-cadherin was suppressed at both the mRNA and protein levels. This was associated with hypermethylation of the E-cadherin promoter. Depressed E-cadherin correlated with HBxAg trans-activation function, as did the migration of HepG2 cells in vitro. Decreased expression of E-cadherin was also associated with the accumulation of β-catenin in the cytoplasm and/ or nuclei in tissues and cell lines, which is characteristic of activated β-catenin. Additional work showed that HBxAg-activated β-catenin. Together, these results suggest that the HBxAg is associated with decreased expression of E-cadherin, accumulation of β-catenin in the cytoplasm and nucleus, and increased cell migration, which may contribute importantly to hepatocarcinogenesis. © 2006 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Liu, Jing
United States, Philadelphia
Thomas Jefferson University
China, Xi'an
Xijing Hospital
Lian, Zhaorui
United States, Philadelphia
Thomas Jefferson University
Han, S.
China, Xi'an
Xijing Hospital
Waye, Mary Miu Yee
Hong Kong, Hong Kong
Chinese University of Hong Kong
Wang, H.
China, Shanghai
Second Military Medical University
Wu, Mengchao
China, Shanghai
Second Military Medical University
Wu, Kaichun
China, Xi'an
Xijing Hospital
Ding, J.
China, Xi'an
Xijing Hospital
Arbuthnot, Patrick B.
South Africa, Johannesburg
University of the Witwatersrand
Kew, Michael Charles
South Africa, Johannesburg
University of the Witwatersrand
Fan, Daiming
China, Xi'an
Xijing Hospital
Feitelson, Mark Alan
United States, Philadelphia
Thomas Jefferson University
United States, Philadelphia
Sidney Kimmel Cancer Center at Jefferson
Statistics
Citations: 115
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1038/sj.onc.1209138
ISSN:
09509232
e-ISSN:
14765594
Research Areas
Cancer
Infectious Diseases